Description

Product Description

Anrikefon (CAS 2269511-95-5), also known as HSK21542, is a synthetic research compound that functions as a kappa opioid receptor (KOR) agonist. Opioid receptors (mu, delta, and kappa) are critical regulators of pain perception, reward processing, and stress responses. Unlike mu-opioid receptor agonists, which are associated with addictive liability, kappa receptor agonists are under investigation as alternative analgesics with reduced abuse potential.

Background and Significance

The opioid system plays a central role in modulating nociception and stress responses. While classical opioids such as morphine primarily activate the mu-opioid receptor (MOR), leading to strong analgesia but also dependence and tolerance, selective kappa receptor agonists like Anrikefon provide a different pharmacological profile. KOR agonists offer analgesia through distinct signaling pathways without the same level of euphoric reinforcement, making them highly valuable for research in non-addictive pain therapeutics.

Anrikefon has been optimized for selectivity, potency, and safety in experimental models, providing a reliable pharmacological tool for studying opioid receptor signaling, neurobiology, and pain physiology.

Chemical Properties and Research Utility

• Compound Class: Synthetic peptide-based opioid receptor agonist

• Primary Target: Kappa opioid receptor (KOR)

• Effect: Analgesia, antinociception, and modulation of stress-related signaling

• Research Applications: Pain physiology, opioid receptor pharmacology, neuropsychiatric disorders

Anrikefon provides unique advantages compared to other opioid receptor ligands, allowing researchers to explore kappa-specific signaling without significant mu-receptor-mediated confounding effects.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action

Anrikefon acts as a selective kappa opioid receptor agonist, binding to KORs located in the central and peripheral nervous system. Upon activation:

• Analgesic Effect: KOR agonism reduces nociceptive transmission in the spinal cord and brain regions associated with pain perception.

• Anti-Pruritic Effect: KOR activation reduces itch signaling, making it useful for dermatological pain/itch models.

• Stress and Mood Modulation: KOR agonism regulates stress pathways in the hypothalamic-pituitary-adrenal (HPA) axis.

• Reduced Abuse Potential: Unlike MOR agonists, KOR agonists lack strong reinforcing effects, lowering addiction liability in preclinical models.

Research Applications

1. Pain and Analgesia Studies
   Anrikefon is used to study central and peripheral pain mechanisms, including neuropathic and inflammatory pain models.

2. Opioid Receptor Pharmacology
   Provides insights into KOR signaling pathways compared to mu- and delta-opioid receptor ligands.

3. Addiction Research
   Helps evaluate potential opioid analgesics with reduced risk of dependence.

4. Stress and Neuropsychiatric Disorders
   KOR signaling is implicated in stress, depression, and anxiety models, making Anrikefon a tool for CNS research.

5. Drug Development Models
   Supports the design of next-generation non-addictive analgesics and KOR-selective therapeutics.

   

Side Effects (For Reference in Research Models)

In laboratory research models, the following effects have been noted for KOR agonists such as Anrikefon:

• Dysphoria or Mood Alterations: Some animal models report aversive behavioral responses.

• Motor Impairment: High doses may affect locomotor activity.

• Sedation: CNS depression has been observed in experimental studies.

• Stress Response Changes: Prolonged exposure may alter stress hormone signaling.

• Species-Specific Sensitivity: Effects may differ across rodent and primate models.

• Tolerance with Chronic Use: Extended dosing may reduce analgesic efficacy over time.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Anrikefon CAS 2269511-95-5

• Anrikefon HSK21542

• Kappa opioid receptor agonist peptide

• Non-addictive analgesic research compound

• GMP-grade opioid receptor agonist

• Anrikefon pain research peptide

• KOR agonist for CNS research

• Anrikefon bulk supplier

• Laboratory-grade kappa opioid agonist

• Research use only opioid receptor ligand