Argipressin acetate | CAS No. 129979-57-3

Description

Product Description

Argipressin acetate (CAS 129979-57-3), commonly referred to as Arg8-vasopressin acetate, is a synthetic peptide analog of the natural hormone vasopressin. It is well-characterized for its ability to bind and activate vasopressin receptors—V1, V2, and V3—making it highly valuable for vascular biology, renal physiology, and neuroendocrine research.

Background on Vasopressin and Its Analogs

• Vasopressin (antidiuretic hormone, ADH) regulates blood pressure, water balance, and stress responses.

• Native vasopressin suffers from rapid degradation; thus, Argipressin acetate, a stabilized analog, is widely used in research.

• Its high receptor affinity enables precise study of signal transduction pathways related to vascular smooth muscle contraction, kidney function, and pituitary hormone secretion.

Research Applications

1. Vascular Research

   • Binds to V1 receptors in vascular smooth muscle, inducing vasoconstriction.

   • Useful in models of blood pressure regulation and vascular reactivity.

2. Renal Physiology

   • Through V2 receptor activation, enhances water reabsorption in collecting ducts.

   • Plays a role in studies of diabetes insipidus and fluid balance disorders.

3. Neuroendocrinology

   • V3 receptor binding influences ACTH secretion in the anterior pituitary.

   • Important for stress hormone regulation research.

4. Pathophysiological Models

   • Investigated in hypertension, shock, sepsis, and endocrine dysfunctions.

   • Serves as a pharmacological tool to dissect vasopressin signaling pathways.

Product Specifications

Mechanism of Action

Argipressin acetate acts as a ligand for vasopressin receptors:

1. V1 Receptor Binding (Vascular Effects)

   • Located in vascular smooth muscle cells.

   • Binding activates Gq-protein-coupled pathways, leading to phospholipase C activation, IP3 generation, and calcium mobilization.

   • Results in vasoconstriction and regulation of systemic blood pressure.

2. V2 Receptor Binding (Renal Effects)

   • Expressed in kidney collecting ducts.

   • Activates Gs-protein-coupled signaling, increasing cAMP and promoting aquaporin-2 insertion into apical membranes.

   • Enhances water reabsorption and maintains fluid homeostasis.

3. V3 Receptor Binding (Neuroendocrine Effects)

   • Located in anterior pituitary corticotroph cells.

   • Stimulates ACTH release through intracellular signaling cascades.

   • Influences hypothalamic-pituitary-adrenal (HPA) axis activity.

4. Systemic Physiological Integration

   • Simultaneous modulation of vascular tone, water balance, and stress hormone release.

   • Provides a powerful model for studying integrative physiology and pharmacology.

     

Side Effects

Observed in Research Models

• Excessive vasoconstriction, potentially leading to hypertension.

• Hyponatremia, due to enhanced renal water reabsorption.

• Endocrine disturbances, from elevated ACTH secretion.

Potential Risks

• Risk of vascular ischemia if vasoconstriction is prolonged.

• Imbalances in electrolyte homeostasis.

• Stimulation of inappropriate HPA axis activity under stress models.

Safety Notes

• For laboratory use only.

• Handle under sterile peptide handling procedures.

• Avoid repeated freeze-thaw cycles to preserve activity.

Disclaimer

This product is intended for research use only. Argipressin acetate is not approved for diagnostic or therapeutic applications in humans.

Keywords

Argipressin acetate, CAS 129979-57-3, Arg8-vasopressin acetate, vasopressin receptor ligand, V1 V2 V3 receptor agonist, vascular smooth muscle peptide, renal physiology peptide, neuroendocrine peptide research.

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