描述
Bevonescein, also known as ALM-488 (CAS 2276787-79-0), is a fluorescein-conjugated peptide-dye tracer designed to bind nerve-associated connective tissue. It enables both intact and degenerated peripheral nerves to fluoresce during real-time imaging—particularly useful in surgical fluorescence-guided models.
Preclinical studies confirm that Bevonescein offers superior visualization of degenerated facial nerves compared to traditional myelin-binding dyes, greatly improving surgical nerve identification in animal models.
Synthesized under GMP conditions, Bevonescein offers high purity and consistent quality for research applications in neuroscience and surgical visualization.
Product Specifications
Parameter | Details |
---|---|
Product Name | Bevonescein (ALM-488) |
Synonyms | ALM-488 |
CAS No. | 2276787-79-0 |
Purity | High-purity (GMP-grade) |
Molecular Formula | C???H???N??O?? |
Molecular Weight | ~2310.5 Da |
Appearance | White to off-white solid |
Solubility | Soluble in DMSO (approx. 100 mg/mL) with ultrasonication; handle using freshly opened DMSO |
Storage Conditions | Store at –20 °C, protected from light and moisture; prepared solutions stable at –80 °C for up to 6 months |
Manufacturing Standard | GMP-compliant |
Applications | Nerve labeling in fluorescence imaging—intact and degenerated nerves |
Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
Bevonescein selectively binds to extracellular nerve-associated connective tissue, illuminating both intact and degenerated peripheral nerves under fluorescence-guided imaging. It delivers superior contrast for in vivo surgical and ex vivo imaging models, aiding researchers in neurosurgical visualization, nerve regeneration, and surgical monitoring.
Side Effects (For Reference Only)
Bevonescein is strictly for experimental research use. No human safety or toxicity data is available. Standard laboratory safety measures must be followed.
Disclaimer
This product is intended solely for laboratory research. It is not approved for human or veterinary clinical use. Please follow institutional safety protocols when handling.
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