Bredinin Mizoribine Tablets 25?mg – (For Research Use Only)
$1.00
Bredinin Mizoribine Tablets contain 25?mg of mizoribine per tablet, supplied in bottles of 100 by Asahi Kasei Pharma Corporation. Approved under registration H20140243 (Japan origin). Widely used in laboratory research on lymphocyte proliferation inhibition, nephropathy models, and immunosuppressive mechanisms. Suitable for wholesale and retail. For research use only.?For wholesale prices, other specifications and uses, please consult our staff?
描述
Bredinin (mizoribine) is a proprietary imidazole nucleoside that selectively inhibits inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase, halting guanine nucleotide synthesis and arresting DNA synthesis in the S phase. It exhibits immunosuppressive activity with less toxicity compared to azathioprine. Clinically used in transplant tolerance, nephrotic syndrome, lupus nephritis, rheumatoid arthritis and IgA?mediated renal conditions. In research, mizoribine tablets are used to model lymphocyte suppression, glomerular injury pathways, autoimmune arthritis, and renal inflammation. Each tablet delivers 25?mg of mizoribine. For laboratory research use only.
Product Specifications
| Parameter | Detail |
|---|---|
| Product Name | Bredinin Mizoribine Tablets |
| Strength | 25?mg per tablet |
| Packaging Size | 100 tablets per bottle |
| Dosage Form | Oral film-coated tablet |
| Manufacturer | Asahi Kasei Pharma Corporation, Nagoya Plant (Japan) |
| Registration Number | ???? H20140243 |
| Drug Standard Code | 86979166000387 |
| Barcode | Not yet assigned |
| CAS Number | 50924?49?7 |
| Molecular Formula | C?H??N?O? |
| Molecular Weight | ~259.22 |
Mechanism of Action & Research Applications
Mizoribine acts as an inhibitor of IMPDH and GMP synthetase, suppressing guanine nucleotide synthesis and preventing DNA replication in proliferating lymphocytes. In research, Bredinin is employed to model immunosuppression in renal transplantation, study nephrotic syndrome pathways, modulate autoimmune responses in lupus and arthritis models, and test novel inflammation-suppressing protocols. Its specificity for lymphocyte proliferation makes it ideal for controlled immunology studies.
Side Effects (For Reference Only in Research Models)
Experimental data and clinical analogs report potential effects including mild gastrointestinal upset, reversible leukopenia or elevated liver enzymes, and occasional rash. Its toxicity profile is lower than comparable immunosuppressants, but safety monitoring for hematologic or hepatic parameters is advised during experimental dosing.
Disclaimer
Bredinin Mizoribine Tablets are strictly intended for laboratory research use only. Not for human or veterinary therapeutic or diagnostic use.
其他信息
| 重量 | 0.6 公斤 |
|---|---|
| 尺寸 | 23 × 36 × 23 厘米 |
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