2: PN: US20040072744 SEQID: 2 claimed protein | CAS 389572-87-6 | Synthetic Peptide for Down’s Syndrome and Schizophrenia Research

Description

Product Description

2: PN: US20040072744 SEQID: 2 claimed protein CAS 389572-87-6 is a synthetic peptide derived from the sequence disclosed in US patent US20040072744 (SEQID: 2). This peptide is primarily used in preclinical neuroscience research, with applications in modeling and mechanistic studies of neurodevelopmental and psychiatric disorders.

Biological Significance

The peptide is implicated in studies of Down’s syndrome (trisomy 21) and schizophrenia, where molecular dysfunctions at synaptic, neuronal signaling, and cognitive levels are explored. By providing a synthetic analog of native sequences, researchers can dissect specific protein functions, receptor interactions, and intracellular signaling pathways relevant to neurodevelopment and psychiatric conditions.

Mechanistic Insights

Although the precise molecular target may depend on experimental design, this synthetic peptide is utilized to:

• Modulate synaptic activity and neurotransmitter release in neuronal culture models

• Investigate cognitive and behavioral effects in preclinical animal models

• Examine molecular pathways altered in Down’s syndrome and schizophrenia, such as synaptic plasticity, NMDA receptor signaling, and neurodevelopmental transcriptional networks

Applications

Key experimental applications include:

• Down’s syndrome research: Exploring pathways disrupted in trisomy 21, including neuronal differentiation, synapse formation, and cognitive function.

• Schizophrenia research: Studying synaptic dysfunction, neurotransmitter imbalances, and cellular signaling deficits.

• Drug discovery and mechanistic studies: Serving as a tool to validate potential therapeutic targets or interventions.

• In vitro and in vivo neuroscience models: Used in cell cultures, organoids, and rodent models to evaluate neuronal and behavioral outcomes.

Experimental Handling

• Supplied as a lyophilized powder

• Soluble in water, PBS, or DMSO for in vitro and in vivo applications

• Store at −20 °C, dry and protected from light

• Handle under standard biosafety protocols

Product Specifications

Mechanism of Action

2: PN: US20040072744 SEQID: 2 claimed protein CAS 389572-87-6 functions as a synthetic analog peptide with activity relevant to neurodevelopmental and psychiatric research:

1. Synaptic Modulation

The peptide may interact with neuronal receptors or signaling proteins to modulate synaptic activity, neurotransmitter release, and plasticity.

2. Neurodevelopmental Pathways

In Down’s syndrome models, the peptide is used to study disrupted developmental signaling pathways, including:

• Neuronal differentiation

• Axonal growth

• Synapse formation

3. Psychiatric Disorder Modeling

In schizophrenia research, the peptide allows examination of:

• NMDA receptor signaling and associated downstream cascades

• Dopaminergic and glutamatergic synaptic modulation

• Behavioral outcomes in preclinical models

4. Mechanistic Studies

• Investigates molecular pathways altered in neurodevelopmental and psychiatric conditions

• Evaluates effects on intracellular signaling, transcriptional networks, and synaptic function

5. Integration in Experimental Research

The peptide is compatible with:

• Neuronal cell cultures, including primary and induced pluripotent stem cell-derived neurons

• Brain organoids for developmental studies

• Rodent behavioral models for cognitive and psychiatric endpoints

  

Side Effects

In experimental research, this synthetic peptide demonstrates:

• Minimal cytotoxicity in standard neuronal culture concentrations

• No observed mutagenicity or genotoxicity in standard preclinical models

• Handling should follow standard peptide and biosafety protocols

Keywords

2: PN: US20040072744 SEQID: 2 claimed protein, CAS 389572-87-6 ,synthetic peptide, Down’s syndrome research, schizophrenia research, neurodevelopmental peptide, synaptic function, neuronal signaling, preclinical neuroscience, NMDA receptor modulation, cognitive disorder model

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All CAS 389572-87-6 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.