描述
Product Specifications
| Attribute |
Details |
| Product Name |
Celecoxib Capsules |
| Generic Name |
Celecoxib |
| CAS Number |
169590?42?5 |
| Molecular Formula |
C??H??F?N?O?S |
| Molecular Weight |
~381.37?g/mol |
| Dosage Form |
Oral capsule |
| Strength |
200?mg per capsule |
| Pack Size |
(e.g., 30 capsules) |
| Manufacturing Approval |
N/A (research grade) |
| Manufacturer |
Sichuan Xinston Pharmaceutical |
| Storage |
Store at 15–25?°C, protect from moisture and light |
| Intended Use |
Laboratory research use only |
Mechanism of Action
Celecoxib selectively inhibits cyclooxygenase?2 (COX?2), reducing prostaglandin synthesis involved in inflammation, pain, and fever—while sparing COX?1, reducing gastrointestinal side effects in research models.
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Research Applications & Pharmacology
-
Inflammation & pain models: Used in osteoarthritis, rheumatoid arthritis, nociceptive pain, and dysmenorrhea studies.
-
Cancer/prevention models: Investigated for chemoprevention in familial adenomatous polyposis and COX?2?dependent tumor biology (e.g., colorectal, neuroblastoma).
-
Cardiovascular risk profiling: Employed in studies assessing thrombotic risk and COX?2 inhibitor safety.
-
Pharmacokinetics: Well absorbed, peak plasma 2–4 hrs, half-life ~6–12 hrs, highly protein?bound (~97%), metabolized by CYP2C9/CYP3A4 to inactive metabolites excreted in urine/feces.
Safety Profile & Handling
Common adverse effects (clinical/preclinical context):
-
GI: bleeding, ulceration, perforation
-
Cardiovascular: increased risk of MI and stroke
-
Others: headache, dizziness, hypertension, renal and hepatic effects
Lab handling recommendations:
-
Use personal protective equipment and follow standard handling for NSAIDs.
-
Monitor study models for GI, cardiovascular, renal, and hepatic markers.
-
Use lowest effective dose for shortest duration.
-
Dispose of unused material as chemical waste.
?? Research?Use Disclaimer
This product is intended solely for laboratory research, and is not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may pose safety risks and compromise data integrity.
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