描述
Clozapine is a second-generation (atypical) antipsychotic that exhibits high affinity for dopamine D4, serotonin 5-HT2A, and several muscarinic, adrenergic, and histaminergic receptors. It is primarily used in experimental settings focused on schizophrenia models, antipsychotic pharmacodynamics, and neurotoxicity mitigation studies. Dispersible tablets offer ease of dissolution for in vitro or controlled in vivo trials.
Clozapine Dispersible Product Specifications
Parameter | Details |
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Product Name | Clozapine Dispersible Tablets |
Active Ingredient | Clozapine |
CAS Number | 5786-21-0 |
Molecular Formula | C18H19ClN4 |
Molecular Weight | 326.83 g/mol |
Formulation | Dispersible oral tablet |
Strength | 25?mg per tablet |
Pack Size | 100 tablets per bottle |
Dosage Form | Tablet |
Approval Number | H20163237 (China NMPA) |
Product Code | 86904206000119 |
Manufacturer | Shouguang Fukang Pharmaceutical Co., Ltd. |
Barcode | 6924165000498 |
Storage Conditions | Store below 25?°C, dry environment |
Intended Use | Laboratory research use only |
Clozapine Dispersible Mechanism of Action
Clozapine antagonizes several neurotransmitter receptors, notably dopamine D1–D5 (especially D4), serotonin 5-HT2A/2C, ?-adrenergic, and muscarinic M1–M5. This broad receptor profile contributes to reduced extrapyramidal side effects compared to first-generation antipsychotics, making it a favored model compound in CNS research.
Clozapine Dispersible Research Applications
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Schizophrenia model studies
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Receptor-binding assays (D4, 5-HT2A, M1)
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Pharmacokinetic profiling of atypical antipsychotics
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Behavioral neuroscience (rat/mouse models)
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Toxicity and metabolic pathway studies
Safety & Handling
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Adverse Effects (lab-reported): Sedation, agranulocytosis risk, hypotension, weight gain
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Precautions: Requires appropriate lab safety protocols due to potential hematological toxicity
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Handling: Use gloves and work in well-ventilated lab areas
Research Use Disclaimer
This product is intended exclusively for laboratory research use. It is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Improper or unauthorized use may pose serious health hazards. Always follow institutional biosafety protocols.
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