描述
Desvenlafaxine is the active metabolite of venlafaxine and functions as an SNRI. It is often utilized in preclinical CNS studies examining neurotransmitter uptake inhibition, mood disorders, and neuroplasticity. This sustained-release formulation ensures prolonged plasma concentration for extended pharmacodynamic observation.
Desvenlafaxine Succinate Product Specifications
Parameter | Details |
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Product Name | Desvenlafaxine Succinate Sustained-release Tablets |
Synonyms | Desvenlafaxine ER, DVS, O-desmethylvenlafaxine |
CAS Number | 93413-62-8 |
Molecular Formula | C16H25NO2 |
Molecular Weight | 263.38 g/mol |
Strength | 50mg per tablet |
Formulation | Sustained-release tablet |
Pack Size | 14 tablets per box |
Dosage Form | Oral tablet |
Approval Number | H20233840 (NMPA, China) |
Drug Code | 86902770004779 |
Manufacturer | CSPC Ouyi Pharmaceutical Co., Ltd. |
Storage Conditions | Store below 25°C, away from moisture |
Intended Use | Laboratory research only |
Desvenlafaxine Succinate Mechanism of Action
Desvenlafaxine acts by selectively inhibiting the reuptake of serotonin and norepinephrine in the CNS. It increases the synaptic concentration of these neurotransmitters, helping stabilize mood in experimental models. Its sustained-release formulation ensures consistent drug levels in long-duration studies.
Research Applications
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Mood Disorder Models
Supports the evaluation of SNRI efficacy in depressive and anxiety-like behaviors in rodents or in vitro systems. -
Neurotransmitter Studies
Useful in serotonin-norepinephrine transport and receptor pathway mapping. -
Chronic Stress Research
Employed in chronic mild stress and neuroendocrine axis studies to simulate human depressive pathology. -
Drug-Drug Interaction Studies
Used in CYP metabolism and transporter interaction profiling.
Safety & Handling
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Handling: Use standard protective equipment in research environments.
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Storage: Keep sealed and dry at room temperature (?25°C).
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Shelf Life: Stable up to 24–36 months when properly stored.
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Disclaimer: Not suitable for human or veterinary use.
Research Use Only Disclaimer
This product is designated solely for laboratory research. It is not intended for therapeutic, diagnostic, clinical, or human consumption. Handle according to institutional biosafety guidelines.
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