Description

Product Description

Dipeptide-2 (N-Valyltryptophan; Val-Trp) is a synthetic dipeptide composed of valine and tryptophan residues linked via a peptide bond. It is a low-molecular-weight bioactive compound primarily studied in cosmetic science for its role in reducing visible signs of aging, improving lymphatic circulation, and promoting skin firmness.

Originally developed for dermatological and cosmeceutical research, Dipeptide-2 has gained significant attention due to its ability to enhance microcirculation and support the skin’s natural drainage system. This helps decrease the accumulation of fluids under the eyes, reducing puffiness and promoting a smoother, more rejuvenated appearance in experimental models.

The peptide is also known to exhibit mild angiotensin-converting enzyme (ACE) inhibitory properties, which may influence local vascular responses and cellular signaling related to skin tone and texture. Through these pathways, Dipeptide-2 contributes to maintaining elasticity and combating dullness associated with fatigue or aging.

Its stable structure and compatibility with a wide range of cosmetic ingredients, including liposomes and emulsifiers, make Dipeptide-2 suitable for formulation studies in anti-aging creams, serums, and eye contour products. Furthermore, its synergistic use with other peptides—such as Palmitoyl Tetrapeptide-7 or Acetyl Hexapeptide-8—has been shown in research to amplify overall skin revitalization effects.

Dipeptide-2’s small molecular size enables deep dermal penetration, allowing it to effectively interact with fibroblast and keratinocyte cells. This interaction promotes increased skin metabolism, potentially improving firmness and smoothness. Consequently, it has become a benchmark ingredient for cosmetic research targeting lymphatic drainage, anti-aging, and fatigue-reducing applications.

Product Specifications

Mechanism of Action

Dipeptide-2 operates via a multifaceted biological mechanism centered on enhancing microcirculation and modulating enzymatic activity in the dermal and subdermal layers. As an angiotensin-converting enzyme (ACE) modulator, it influences vascular tone and permeability, supporting efficient lymphatic drainage. This effect reduces the pooling of fluids and inflammatory mediators, especially in delicate periorbital regions.

In addition to its vascular effects, Dipeptide-2 demonstrates antioxidant and anti-glycation activity in research studies. These properties help protect skin proteins such as collagen and elastin from oxidative degradation and cross-linking, which are major contributors to visible aging. By maintaining the structural integrity of connective tissues, the peptide contributes to firmer, more elastic skin.

Dipeptide-2 may also influence fibroblast activity, stimulating extracellular matrix remodeling and improving skin resilience. The presence of tryptophan in its structure provides aromatic stability and enhances its interaction with lipid membranes, increasing its bioavailability in topical formulations.

In research formulations, Dipeptide-2 is often incorporated alongside other peptides targeting different pathways of skin aging—such as Matrixyl (Palmitoyl Pentapeptide-4) and Palmitoyl Tripeptide-1—to produce a synergistic lifting and smoothing effect. Its non-irritant nature and biochemical stability make it ideal for studies involving chronic exposure or repeated topical application models.

Side Effects

In laboratory evaluations, Dipeptide-2 is reported to have excellent tolerability and biocompatibility. It does not typically induce irritation, erythema, or sensitivity when tested under controlled cosmetic research conditions. However, concentration and formulation type should always be optimized according to study protocols.

No significant cytotoxicity or mutagenic activity has been reported in vitro. Nonetheless, as with all cosmetic research materials, researchers must handle the peptide under standard laboratory conditions and ensure it is not used in any clinical or human application.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.