Dutasteride Soft Capsules 0.5?mg ×?10 Capsules
$1.00
Dutasteride is a dual 5?-reductase inhibitor that suppresses both type I and II enzymes, reducing dihydrotestosterone (DHT) levels by up to 98%. Supplied in 0.5?mg soft gelatin capsules (10 per pack) by Jiangsu Wangao Pharmaceuticals, this product is intended exclusively for laboratory and preclinical research, including androgen suppression, BPH, and alopecia models. Not approved for clinical, therapeutic, diagnostic, or veterinary use.?Please consult staff for other specifications and uses?
描述
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Dutasteride Soft Capsules |
| Generic Name | Dutasteride |
| CAS Number | 164656?23?9 magistralbr.caldic.com+15en.wikipedia.org+15sciencedirect.com+15accessdata.fda.gov |
| Molecular Formula | C??H??F?N?O? |
| Molecular Weight | ~528.5?g/mol |
| Dosage Form | Oral soft gelatin capsule |
| Strength | 0.5?mg per capsule |
| Pack Size | 10 capsules per box |
| Approval No. | China NMPA H20234210 |
| Product Code | 86901503000569 |
| Manufacturer | Jiangsu Wangao Pharmaceutical Co., Ltd. |
| Barcode | 6938033202990 |
| Storage Conditions | Store at 2–8?°C or 15–25?°C; protect from light |
| Intended Use | Laboratory/preclinical research only |
Mechanism of Action
Dutasteride is an irreversible inhibitor of both type I and II 5?-reductase enzymes, preventing conversion of testosterone to DHT. It reduces serum DHT levels by up to 98%, significantly more than finasteride (~65–70%) .
Research Applications & Pharmacology
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Benign Prostatic Hyperplasia (BPH) Models: Widely used to study prostate volume reduction and LUTS in preclinical contexts .
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Androgenetic Alopecia (AGA) Models: More effective than finasteride in hair growth studies, especially at 0.5?mg dosing .
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Pharmacokinetics: Oral bioavailability ~60%, protein binding ~99%, metabolized via CYP3A4, elimination half-life ~4–5 weeks, mainly excreted in feces (~40%) .
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Research Formulation Impact: Soft gelatin capsules offer higher bioavailability than tablets or hard capsules .
Safety Profile & Handling
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Adverse Effects: Can cause sexual dysfunction, breast tenderness/gynecomastia (~1.3%), depression, and self-harm risks in long-term or high-dose models.
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Drug Interactions/Contraindications: Avoid use in models with CYP3A4 inhibitors; contraindicated in female and pregnant subjects due to teratogenic risk .
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Handling Instructions: Wear lab-safe PPE. Store per label instructions. Dispose of per institutional safety protocols.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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