Exendin (Purity 99.95%, CAS 141758-74-9)

描述

Exendin is a 39-amino-acid peptide originally isolated from the venom of the Gila monster (Heloderma suspectum). It acts as a high-affinity GLP-1 receptor agonist, enhancing glucose-dependent insulin secretion, reducing glucagon levels, slowing gastric emptying, and promoting -cell regeneration.

This peptide is widely used in preclinical studies for Type 2 diabetes, obesity, and neuroendocrine research. Our Exendin?4 is synthesized in certified peptide manufacturing facilities, delivering 99.95% purity verified by HPLC and supported by full documentation, including Certificate of Analysis (COA) and batch traceability.

This product is intended strictly for laboratory research use only. It is not approved for therapeutic or clinical use.

Product Specifications

Mechanism of Action & Research Applications

Exendin?4 binds to and activates the GLP?1 receptor (GLP?1R), mimicking the action of endogenous GLP?1 but with increased stability and a prolonged half-life. It enhances cAMP signaling in pancreatic ??cells, promotes insulin secretion, suppresses glucagon, and contributes to glucose homeostasis.

Common research applications include:

• Type 2 diabetes and insulin signaling models

• Obesity and metabolic syndrome studies

• GLP?1 receptor pharmacology

• ??cell proliferation and protection

• Appetite regulation and CNS signaling

• Hepatic steatosis and lipid metabolism studies

Its long-acting activity and receptor selectivity make Exendin?4 a valuable tool in metabolic and endocrinological research.

Side Effects (For Laboratory Reference Only)

In experimental models, Exendin?4 may exhibit the following effects:

• Hypoglycemia (dose-dependent)

• Gastrointestinal effects (e.g., delayed gastric emptying, nausea)

• Weight loss in animal models

• Changes in pancreatic or gut hormone expression

Proper controls and ethical oversight are recommended in in vivo studies.

Disclaimer

This product is supplied exclusively for laboratory research purposes. It is not for human or veterinary use, and is not approved for clinical, therapeutic, or diagnostic applications. Handle with standard lab safety protocols.