Description

Glibenclamide (also known as glyburide) is a second-generation sulfonylurea compound that stimulates insulin secretion from pancreatic beta-cells. It is widely used in laboratory studies focused on insulin signaling, beta-cell sensitivity, glucose uptake, and diabetes mellitus type 2 simulation.

This formulation contains 2.5mg of glibenclamide per tablet, packaged in bottles of 100. Produced by Tianjin Pacific Pharmaceutical Co., Ltd. and approved by China NMPA under registration H12020790. Product code: 86900931000455.

For research purposes only. Not for clinical or veterinary use.

Product Specifications

Mechanism & Research Applications

Glibenclamide functions by closing ATP-sensitive potassium channels in pancreatic beta-cell membranes, leading to membrane depolarization, calcium influx, and insulin release. It is a key compound in the study of sulfonylurea receptor pathways, insulin resistance, and glucose homeostasis.

Research applications include:

• Type 2 diabetes model induction

• Insulin secretion studies

• Pancreatic beta-cell function assays

• Sulfonylurea mechanism exploration

• Hypoglycemia threshold modeling

Safety & Handling

• Use Restriction: For laboratory research use only

• Protective Equipment: Gloves, lab coat, eye protection

• Storage: Keep sealed below 25°C

• Disposal: Dispose of via approved chemical waste protocols

• Reactivity: Avoid mixing with oxidizing agents

Research Use Disclaimer

This product is intended strictly for laboratory research use only. It is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Any misuse may result in safety, ethical, or legal consequences. Always follow your institution’s biosafety and research handling guidelines.