Lagatide (CAS 157476-77-2) | raw material GMP Supplier & Manufacturer

描述

Product Description

Lagatide (CAS 157476-77-2, BN 52080) is a heptapeptide designed as a C-terminal analog of sorbin, which modulates intestinal absorption and secretion. Its proabsorptive and antisecretory effects make it a valuable tool for studying intestinal physiology and pathophysiology, particularly in models of chronic diarrhea.

Background and Research Significance

Chronic diarrhea is a common gastrointestinal disorder with multiple etiologies, including infection, inflammation, and secretory dysfunction. Lagatide allows researchers to:

• Investigate intestinal transport mechanisms and absorption-secretion balance.

• Study electrolyte and fluid homeostasis in different intestinal segments.

• Develop therapeutic strategies for diarrhea and related disorders.

Lagatide’s selective activity along the gastrointestinal tract provides mechanistic insight into peptide-mediated regulation of intestinal function. Preclinical studies show that it effectively enhances fluid and nutrient absorption while reducing secretory loss, making it a critical tool for gastrointestinal research.

Chemical Properties and Structure

• Compound Class: Synthetic heptapeptide

• Target: Intestinal absorptive and secretory pathways

• Mechanism: Modulation of electrolyte and water transport

• Activity: Proabsorptive and antisecretory

• Stability: Lyophilized peptide with extended shelf life

• Applications: Gastrointestinal physiology, chronic diarrhea research, electrolyte absorption studies

Lagatide demonstrates high reproducibility and structural stability, enabling reliable experimental results in both in vitro and in vivo preclinical models.

Product Specifications

The specifications guarantee high purity, reproducible proabsorptive and antisecretory activity, and experimental reliability.

Mechanism of Action & Research Applications

Mechanism of Action

Lagatide exerts its effects by modulating intestinal electrolyte and fluid transport:

1. Proabsorptive Activity: Enhances absorption of water and electrolytes across intestinal epithelium.

2. Antisecretory Activity: Reduces secretory losses induced by chemical or bacterial stimuli.

3. Segment-Specific Effects: Acts differently in duodenum, jejunum, ileum, and colon to normalize fluid balance.

Its heptapeptide structure, as a C-terminal analog of sorbin, is critical for receptor binding and functional activity in intestinal epithelial cells.

Research Applications

1. Chronic Diarrhea Models
Study mechanisms and potential therapeutic interventions in preclinical models.

2. Intestinal Fluid Regulation
Investigate water and electrolyte transport in intestinal segments.

3. Gastrointestinal Physiology
Examine peptide-mediated modulation of epithelial absorption and secretion.

4. In Vitro Epithelial Assays
Evaluate Lagatide activity in cultured intestinal cells or tissue explants.

5. Preclinical Peptide Development
Assess structure-activity relationships for therapeutic analogs.

6. Translational Research
Inform development of peptide-based treatments for secretory diarrhea and malabsorption syndromes.

7. Combination Studies
Test synergistic effects with other gastrointestinal modulators or antidiarrheal agents.

8. Mechanistic Pathway Analysis
Study signal transduction pathways involved in proabsorptive and antisecretory activity.

9. Dose-Response Studies
Evaluate minimal effective doses and saturation kinetics in various intestinal models.

10. Laboratory Protocol Optimization
Supports robust experimental design for gastrointestinal physiology research.

Side Effects (For Reference in Research Models)

Preclinical observations include:

• Fluid Balance Effects: Dose-dependent absorption changes may influence electrolyte levels.

• Species-Specific Responses: Activity may vary between rodents and higher mammals.

• Stability Considerations: Avoid repeated freeze-thaw cycles to maintain peptide activity.

• Combination Effects: Co-treatment with other peptides may modify absorption or secretion profiles.

These observations are strictly for laboratory research reference. Lagatide is not for human or veterinary use.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Lagatide CAS 157476-77-2

• BN 52080 peptide

• C-terminal sorbin analog

• Proabsorptive intestinal peptide

• Antisecretory gastrointestinal peptide

• Chronic diarrhea research peptide

• Laboratory gastrointestinal peptide

• GMP-grade Lagatide

• Preclinical absorption studies

• Research use only intestinal agent