Description

Product Description

Mazdutide (IBI362) is a cutting-edge dual agonist research compound designed to support advanced investigations in metabolic regulation, weight balance, incretin biology, and glucagon-mediated thermogenic pathways. Supplied as a high purity, GMP-aligned, factory manufactured lyophilized powder, Mazdutide (IBI362) provides researchers with exceptional quality, reproducibility, and scalability for both small-scale exploratory studies and large-volume wholesale research programs. Its robust dual-agonism on the GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR) makes it a uniquely powerful tool for dissecting multi-hormonal metabolic signaling networks that cannot be fully explored through single-receptor analogs.

As a GLP-1 pathway activator, Mazdutide (IBI362) supports research into appetite suppression mechanisms, glucose-regulated insulin secretion, gut–brain metabolic communication, and gastrointestinal motility modulation. At the same time, its GCGR activity allows the examination of hepatic glucose output, lipid oxidation, metabolic heat generation, and whole-body energy expenditure. The synergistic effects emerging from its dual agonist nature enable detailed investigations into coordinated incretin–glucagon crosstalk, a key focus in next-generation obesity and metabolic disorder therapeutics research.

Our factory manufactured processes ensure that each vial of high purity Mazdutide (IBI362) undergoes rigorous analytical QC—including HPLC, MS, and identity confirmation—to deliver stable and reproducible performance across studies. This is particularly valuable in multi-phase metabolic projects that rely on consistent biological activity, such as long-term obesity model interventions, hepatic remodeling analysis, and transcriptomic screening of thermogenic pathways. Researchers rely on our wholesale supply system to secure uninterrupted batch continuity, customized vial fills, and cost-efficient large-order procurement.

The unique biochemical profile of Mazdutide (IBI362) positions it as a highly effective tool for evaluating integrated metabolic outcomes, such as reductions in adiposity, shifts in fuel utilization, changes in resting energy expenditure, and improvements in glucose–lipid homeostasis. Its dual activation pattern provides a strong foundation for exploring mitochondrial activity, adipose browning, liver lipid turnover, and central metabolic signaling. Studies comparing GLP-1-only agonists versus dual agonist compounds increasingly highlight the broader, more dynamic metabolic landscape accessible through Mazdutide (IBI362).

For research teams conducting omics-driven or computationally enhanced studies, Mazdutide (IBI362) is compatible with multi-omic profiling strategies that integrate transcriptomics, proteomics, metabolomics, and pathway modeling. The consistent quality of our high purity, factory manufactured, and wholesale-available material enables fine-grained analysis of variations in metabolic reprogramming across tissues such as liver, adipose, pancreas, and hypothalamus.

Provided exclusively as a lyophilized powder, Mazdutide (IBI362) is optimized for stability, long-term storage, and flexible solution preparation for controlled experimental conditions. It is intended strictly for laboratory research and not for human or veterinary use. With its powerful dual mechanism, strong stability profile, and scalable wholesale supply chain, Mazdutide (IBI362) stands as one of the most versatile and impactful research tools available for modern metabolic science.

Product Specifications

Mechanism of Action 

The mechanism of action of Mazdutide (IBI362) is defined by its advanced dual agonist activity on both the GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR). This dual-receptor activation distinguishes Mazdutide (IBI362) from traditional incretin analogs and grants researchers a powerful model for dissecting metabolic, endocrine, and thermogenic pathways. As a high purity, factory manufactured, research-grade lyophilized powder, Mazdutide (IBI362) delivers consistent biological performance essential for metabolic studies and wholesale-scale experimentation.

GLP-1 Receptor Activation

Through potent stimulation of the GLP-1 receptor, Mazdutide (IBI362) promotes glucose-dependent insulin secretion, suppresses inappropriate glucagon release, delays gastric emptying, and activates appetite-regulating neural circuits. These actions collectively support investigations into weight-loss mechanisms, satiety signaling, and glycemic modulation. Researchers studying pancreatic islet biology, gut–brain communication, and hypothalamic metabolic pathways rely heavily on the consistent functionality of high purity Mazdutide (IBI362).

Glucagon Receptor Activation

In parallel, the stimulation of the glucagon receptor enables exploration of hepatic glucose output, fatty-acid oxidation, mitochondrial thermogenesis, and whole-body energy expenditure. The GCGR pathway provides a distinct metabolic profile that cannot be obtained from GLP-1 agonism alone. This makes Mazdutide (IBI362) a superior dual agonist model for studying lipid turnover, heat production, and metabolic flexibility.

Synergistic Dual-Agonist Integration

The synergy between GLP-1 and GCGR activation allows Mazdutide (IBI362) to reveal complex biological interactions, such as coordinated signaling cascades, transcriptomic remodeling, and enhanced energy-expenditure dynamics. This integrated mechanism supports multi-omic research strategies and computational pathway modeling, especially when long-term supply from wholesale, factory manufactured, lyophilized powder batches ensures consistency.

Applications 

The research applications of Mazdutide (IBI362) span a wide spectrum of metabolic, endocrine, and energy-regulation studies, making this high purity, factory manufactured, dual agonist compound one of the most versatile tools for modern metabolic science. As a GLP-1 and glucagon receptor modulator supplied in lyophilized powder form with reliable wholesale availability, Mazdutide (IBI362) supports both fundamental mechanistic investigations and large-scale preclinical research programs.

Metabolic Disease Research

Mazdutide (IBI362) is widely used to explore obesity, insulin resistance, and glucose-lipid regulation. Its dual agonist activation pattern allows researchers to compare GLP-1–only pathways versus combined GLP-1 and GCGR signaling, providing richer biological insights. These models help identify metabolic signatures associated with weight reduction, improved glycemic control, and long-term metabolic remodeling.

Energy Expenditure & Thermogenesis

The compound is ideal for studying mitochondrial thermogenesis, brown adipose tissue activation, and energy-expenditure pathways. By simultaneously activating GLP-1 and the glucagon receptor, Mazdutide (IBI362) enables researchers to analyze fuel-switching mechanisms, lipid oxidation rates, and metabolic flexibility. The consistency provided by high purity, factory manufactured batches ensures reproducible energy-metabolism outcomes.

Hepatic & Lipid Biology

Because GCGR signaling plays a critical role in hepatic fat turnover and gluconeogenesis, Mazdutide (IBI362) supports investigations into NAFLD, NASH, hepatic lipid efflux, and metabolic inflammation. This helps identify transcriptomic and proteomic remodeling patterns driven by dual agonist activity.

Drug Discovery & Comparative Pharmacology

Researchers use Mazdutide (IBI362) to benchmark dual-agonist activity against standard incretin analogs, enabling precise evaluation of receptor-balance strategies and downstream signaling dynamics. The availability of wholesale, factory manufactured supply makes it suitable for long-term pharmacology programs, dose-response mapping, and comparative translational studies.

Research Models 

Research involving Mazdutide (IBI362) leverages a diverse collection of metabolic and endocrine model systems designed to reflect the complex biology influenced by its dual agonist activity. Because Mazdutide (IBI362) simultaneously targets the GLP-1 receptor and the glucagon receptor, researchers rely on specialized models that can capture glucose regulation, lipid turnover, thermogenesis, and energy-expenditure dynamics. The availability of high purity, factory manufactured, and wholesale-ready lyophilized powder ensures batch consistency across long-term projects and cross-laboratory studies.

Diet-Induced Obesity (DIO) Rodents

DIO mice and rats remain the most widely used models for evaluating metabolic outcomes from Mazdutide (IBI362). These animals exhibit excess adiposity, impaired glucose control, and altered metabolic signaling, making them ideal for studying changes caused by GLP-1 activation and dual agonist GCGR pathways. Researchers measure body-weight response, food intake, thermogenic output, and transcriptomic remodeling under controlled dosing protocols.

Genetic Obesity Models

Genetic models such as ob/ob, db/db, and MC4R-deficient strains provide highly reproducible systems for assessing Mazdutide (IBI362) in severe metabolic dysfunction. These models allow analysis of hypothalamic signaling, adipose remodeling, and pancreatic islet responses influenced by GLP-1–GCGR interactions. The stability of high purity Mazdutide (IBI362) ensures that receptor-level effects remain consistent across extended timelines.

Liver & Lipid Metabolism Models

Because the glucagon receptor plays a central role in hepatic glucose production and lipid oxidation, liver-centered models such as NAFLD/NASH rodents or high-fat/high-sucrose diets provide deep insight into GCGR-mediated pathways. Here, Mazdutide (IBI362) enables characterization of hepatic thermogenesis, mitochondrial activation, and metabolomic signatures associated with dual agonist action.

Multi-Omic & Energy-Expenditure Platforms

Studies incorporating metabolic chambers, indirect calorimetry, RNA-seq, proteomics, and lipidomics benefit from the precision of factory manufactured, wholesale-supplied lyophilized powder. These models help quantify fuel switching, energy balance, and molecular pathway integration in response to Mazdutide (IBI362).

Experimental Design Considerations 

Designing experiments with Mazdutide (IBI362) requires careful planning to ensure reproducibility, accurate pathway interpretation, and stable compound performance. Because Mazdutide (IBI362) is a dual agonist targeting both the GLP-1 receptor and the glucagon receptor, researchers must account for its multi-pathway metabolic effects when developing dosing strategies, control groups, and analytical endpoints. The use of high purity, factory manufactured, lyophilized powder ensures consistent quality, particularly in long-term metabolic or pharmacology studies supported by wholesale supply.

Researchers should standardize reconstitution methods to preserve compound integrity and avoid freeze–thaw cycles that may affect dual agonist receptor activity. Dosing schedules should align with circadian metabolic rhythms, especially in rodent models where GLP-1 signaling interacts with feeding cycles. Comparative study arms using mono-agonists or GCGR-only activators can help differentiate the integrated actions of Mazdutide (IBI362).

Multi-omic data acquisition—such as RNA-seq, proteomics, and metabolomics—can provide deeper insights into systemic responses to Mazdutide (IBI362). Combining metabolic chambers, calorimetry, and body-composition analysis enables precise measurement of fuel utilization and thermogenesis driven by dual agonist activation. Using consistent batches from factory manufactured, wholesale-supplied lyophilized powder ensures reproducibility across extended multi-phase experiments.

Laboratory Safety & Handling Guidelines 

Handling Mazdutide (IBI362) requires strict adherence to laboratory safety protocols to ensure researcher protection and compound integrity. As a high purity, factory manufactured, dual agonist lyophilized powder targeting GLP-1 and the glucagon receptor, Mazdutide (IBI362) must be treated as a research-only compound. Direct contact, inhalation, or ingestion should be strictly avoided, and all work should be conducted in a controlled laboratory environment.

Personal protective equipment (PPE) including gloves, lab coat, and eye protection is mandatory. When reconstituting Mazdutide (IBI362), use sterile buffers and avoid repeated freeze–thaw cycles to preserve high purity and receptor activity. Storage should be maintained at –20°C to –80°C, protected from light, to ensure stability for both small-scale studies and wholesale batch experiments.

All handling and disposal procedures should comply with institutional guidelines for hazardous or bioactive research chemicals. Spills should be contained immediately, and contaminated materials should be treated as hazardous waste. Researchers are advised to document all handling procedures for Mazdutide (IBI362) to maintain consistency, particularly in multi-phase metabolic studies.

By following these Laboratory Safety & Handling Guidelines, investigators can safely utilize Mazdutide (IBI362) in a variety of GLP-1 and dual agonist research applications, while maintaining the integrity of the factory manufactured, high purity, lyophilized powder and ensuring reproducible results across wholesale-level experimental programs.

Integration with Multi-Omic & Computational Studies 

Mazdutide (IBI362) offers a powerful platform for integration with multi-omic and computational research approaches due to its dual agonist activity targeting both GLP-1 and the glucagon receptor. As a high purity, factory manufactured, lyophilized powder, Mazdutide (IBI362) ensures consistent, reproducible data acquisition across transcriptomics, proteomics, metabolomics, and systems biology studies, enabling researchers to uncover comprehensive metabolic and signaling networks.

Transcriptomics

The activation of GLP-1 and GCGR pathways by Mazdutide (IBI362) modulates gene expression in key tissues such as liver, adipose, pancreas, and hypothalamus. RNA-seq and single-cell transcriptomics allow researchers to map the dynamic transcriptional responses to dual agonist stimulation, providing insight into appetite regulation, thermogenesis, and lipid metabolism.

Proteomics

Proteomic analyses using Mazdutide (IBI362) enable identification of downstream signaling proteins, receptor interaction networks, and metabolic pathway modifications. The use of high purity, factory manufactured material ensures batch-to-batch consistency, critical for reproducible comparative studies across multiple wholesale experimental replicates.

Metabolomics

Metabolomic profiling reveals the effects of Mazdutide (IBI362) on glucose–lipid flux, ketone body production, and energy expenditure. Researchers can correlate metabolic changes with GLP-1–GCGR dual agonism to identify novel biomarkers and characterize systemic metabolic remodeling.

Computational Biology & Systems Modeling

Integrating Mazdutide (IBI362) data with computational models allows simulation of dual receptor signaling networks, prediction of metabolic outcomes, and optimization of experimental designs. Multi-omic datasets combined with computational analysis facilitate mechanistic insights into energy balance, hepatocyte metabolism, and thermogenic regulation driven by dual agonist activity.

The consistency of factory manufactured, high purity, lyophilized powder Mazdutide (IBI362) supports reliable integration into large-scale wholesale experimental designs, ensuring reproducible, high-quality multi-omic and computational outputs.

Keywords

Mazdutide, IBI362, GLP-1 agonist, glucagon agonist, dual agonist peptide, metabolic peptide, obesity research peptide, diabetes research peptide, GMP peptide, OEM peptide supply, bulk peptide powder, lyophilized peptide

Shipping Guarantee 

All shipments are transported in temperature-controlled packaging (2–8 °C) with moisture protection and tamper-evident seals to preserve Mazdutide (IBI362) lyophilized powder stability. Each order includes batch documentation, COA, MSDS, and real-time tracking. Global logistics ensure timely delivery to research institutions. Our packaging is validated to maintain integrity throughout international transit. For large-scale wholesale orders, specialized cold-chain logistics are implemented to ensure uninterrupted quality and activity of high purity, factory manufactured Mazdutide (IBI362). Researchers can monitor shipments at all times, minimizing risk during global delivery.

Trade Assurance 

Factory-direct GMP production ensures high-purity Mazdutide (IBI362) with consistent batch reproducibility. OEM customization, bulk quantities, and specialized packaging are available for institutional and industrial research. Full documentation is supplied with every shipment for compliance and traceability. Quality and delivery timelines are guaranteed as part of our research-grade assurance system. All dual agonist Mazdutide (IBI362) batches undergo stringent QC verification to maintain uniform activity across multiple wholesale deliveries. Customers benefit from both regulatory-compliant documentation and consistent peptide integrity for long-term experimental programs.

Payment Support 

We support a wide range of international payment methods, including bank transfer, corporate credit, PayPal, major credit cards, and cryptocurrency for eligible partners. Bulk and OEM orders may use flexible payment terms designed for research institutions. All transactions are secure, auditable, and compliant with global procurement standards. Our payment system ensures fast and reliable ordering for laboratories worldwide. For recurring wholesale orders of factory manufactured, high purity Mazdutide (IBI362), tailored invoicing and contractual arrangements are available to support multi-phase research programs.

Disclaimer 

Mazdutide (IBI362) Lyophilized Peptide Powder is for laboratory research use only. It is not intended for human or veterinary use, therapeutic application, or consumption. Researchers must follow institutional biosafety guidelines and regulatory protocols when handling this peptide. All studies should be conducted in controlled laboratory environments. The manufacturer and distributor are not responsible for misuse, and strict adherence to laboratory safety standards is required when utilizing this high purity, factory manufactured, dual agonist Mazdutide (IBI362). Researchers should verify compliance with local regulations before ordering or handling.

References 

1. PubChem – GLP-1 receptor agonists

2. UniProt – GLP-1 Receptor (GLP1R)

3. UniProt – Glucagon Receptor (GCGR)

4. RCSB Protein Data Bank – GLP-1R structures

5. ScienceDirect – Dual-agonist peptides in metabolic research