Description

N?Acetylcysteine (NAC) is the N-acetyl derivative of L?cysteine, crucial for boosting intracellular glutathione and detoxifying harmful metabolites like NAPQI in acetaminophen toxicity. It also acts as a mucolytic, breaking down disulfide bonds in mucus, making it vital for research involving liver injury, respiratory diseases, oxidative stress, and drug-induced organ damage

Product Specifications

Mechanism of Action

NAC acts in three main ways:

1. Replenishes glutathione to counter oxidative stress and detoxify reactive metabolites.

2. Provides a thiol group to directly neutralize NAPQI in acetaminophen exposure.

3. Breaks disulfide bonds in mucus, reducing its viscosity .

Research Applications

• Protection against acetaminophen-induced liver injury and fulminant liver failure.

• Mitigation of oxidative stress and inflammation in pancreatitis and SIRS.

• Mucolytic therapy models in respiratory disease research (e.g., COPD, pneumonia).

• Antioxidant and detox studies involving chemical, drug, and environmental exposures.

Safety & Handling

• Dosage in research models: Varies widely; human clinical infusion dose = 200?mg/ml over several hours; lab protocols differ.

• Side effects: Possible nausea, rash, bronchospasm, hypotension if infused too rapidly.

• Contraindications: Known hypersensitivity to NAC, asthma with bronchospasm history.

• Handling: Use standard lab PPE—gloves, coat, goggles. Avoid rapid infusion.

• Storage: Up to 24 months at ??25?°C, in light- and moisture-protected container.

Core Keywords

N?acetylcysteine injection, NAC 4g vial, acetylcysteine H20051788, CAS 616-91-1, hepatoprotective NAC, antioxidant NAC injection, mucolytic NAC, wholesale NAC vial

Research Use Disclaimer

This product is intended solely for laboratory and research use. It is not approved for therapeutic, clinical, diagnostic, or veterinary application. Misuse may entail legal or health risks. Use only under institutional protocols.