Parecoxib Sodium 40?mg × 10 Vials Wholesale price comparison
$1.00
Parecoxib sodium is a water-soluble injectable prodrug of valdecoxib—a selective COX?2 inhibitor—widely used in perioperative pain and inflammation research. Each vial contains 40?mg parecoxib sodium. Manufactured by Hunan Sailong Pharma (Changsha) Co., Ltd., approved under NMPA H20193217, product code 86979286000151, barcode 6973398250095.
?? For laboratory research use only.?Please consult the staff for other purposes?
描述
Parecoxib-Sodium Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Parecoxib Sodium Injection (Saishulin®) |
| Generic Name | Parecoxib Sodium |
| CAS Number | 15895902 (parecoxib sodium) sciencedirect.com+7en.wikipedia.org+7synapse.patsnap.com+7pubchem.ncbi.nlm.nih.gov |
| Molecular Formula | C??H??N?NaO?S |
| Molecular Weight | ~370.4?g/mol (salt) |
| Dosage Form | Lyophilized powder for IV/IM injection |
| Strength | 40?mg per vial |
| Pack Size | 10 vials per box |
| Approval Number | H20193217 (China NMPA) |
| Product Code | 86979286000151 |
| Manufacturer | Hunan Sailong Pharma (Changsha) Co., Ltd. |
| Barcode | 6973398250095 |
| Storage | Store at 2–8?°C; protect from light |
| Intended Use | Laboratory research use only |
Mechanism of Action
Parecoxib is an injectable prodrug rapidly converted into valdecoxib in the liver, which selectively inhibits COX?2, reducing prostaglandin-mediated pain and inflammation, while sparing COX?1 activity.
Research Applications & Pharmacology
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Perioperative pain models: IV or IM administration at 20–40?mg produces rapid analgesia within 7–14 minutes and lasts up to 24 hours; comparable to ketorolac or morphine.
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Anti-inflammatory studies: Suppresses prostaglandin synthesis, COX?2 pathways, and inflammatory mediators (e.g., IL?1?, IL?6); reduces oxidative stress and postoperative delirium in elderly models .
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Pharmacokinetics: Parecoxib half-life ~22 min; conversion to valdecoxib with ~8?hr half?life; high protein binding (~98%); excreted primarily in urine.
Safety Profile & Handling
Reported effects:
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Rapid analgesic onset with minimal platelet impact .
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Typical COX?2 NSAID risks: GI ulcers, renal impairment, cardiovascular effects; dose-dependent hypotension noted .
Handling guidelines:
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Reconstitute vial with 0.9% NaCl or 5% glucose; administer IV bolus or IM slowly and deeply; flush line before/after use .
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Use PPE, monitor subjects for hemodynamic and renal/hepatic changes.
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Dispose of waste as pharmaceutical hazardous material.
?? Research?Use Disclaimer
This product is intended solely for laboratory research. It is not approved for clinical, therapeutic, diagnostic, or veterinary use. Misuse may pose health risks and COVID compliance issues, and may compromise research integrity.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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