描述
Pradefovir is an innovative liver-targeted nucleotide prodrug of adefovir that inhibits HBV reverse transcriptase, demonstrating potent and specific antiviral effects. It remains stable in plasma and GI, activated in the liver via CYP3A4, leading to lower systemic exposure and improved safety. Clinical studies show efficacy equivalent to tenofovir disoproxil with fewer renal/bone side effects.
Pradefovir Mesylate Tablets Product Specifications
Parameter | Details |
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Product Name | Pradefovir Mesylate Tablets (Xinshumu) |
Generic Name | Pradefovir Mesylate |
CAS Number | 625095?60?5 |
Molecular Formula | C??H??ClN?O?P |
Molecular Weight | ~423.8?g/mol |
Strength | 45?mg per tablet (based on C??H??ClN?O?P) |
Pack Size | 30 tablets per bottle |
Dosage Form | Oral film-coated tablet |
Approval No. | H20240036 (NMPA) |
Drug Code | 86909589000053 |
Manufacturer | Xi’an Gelan Xintong Pharmaceutical Co., Ltd. |
Barcode | 6976282808051 |
Storage Conditions | Store <25?°C, sealed, protected from light and moisture |
Intended Use | Laboratory or preclinical HBV antiviral research |
Pradefovir Mesylate Tablets Mechanism of Action
Pradefovir is a liver-directed prodrug that converts via CYP3A4 to adefovir, which inhibits HBV DNA polymerase, effectively blocking viral replication. Its hepatoselective design reduces systemic exposure and enhances safety.
Pradefovir Mesylate Tablets Research Applications
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Chronic HBV replication suppression
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Pharmacokinetic and pharmacodynamic profiling in liver-targeted therapy
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Resistance and safety comparison with first-line antiviral agents
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Preclinical studies on long-term antiviral efficacy and toxicity
Safety & Handling
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Handling: Use PPE—gloves, lab coat, goggles—avoid ingestion and contact.
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Storage: Keep sealed below 25?°C in a dry, light-protected environment.
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Precautions: For laboratory use only; not for human or veterinary administration.
Core Keywords
pradefovir tablets, pradefovir mesylate 45mg, CAS 625095?60?5, H20240036, antiviral prodrug, liver targeted HBV drug, Xinshumu pradefovir, wholesale pradefovir
Research Use Disclaimer
For laboratory and preclinical research use only. Not approved for clinical, therapeutic, diagnostic, or veterinary applications. Misuse may pose health or regulatory risks. Use under authorized institutional protocols.
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