描述
Sacubitril/Valsartan Sodium Tablets (Yixintan) are a dual-acting cardiovascular research compound combining a neprilysin inhibitor (sacubitril) with an angiotensin II receptor blocker (valsartan). The combination is widely researched for its effects in heart failure, cardiac remodeling, and neurohormonal regulation.
Each tablet contains 100mg of the active compound (sacubitril/valsartan), with 14 tablets per box (7 tablets × 2 blisters). The product is manufactured by Jiangsu Xuantai Pharmaceutical Co., Ltd., approved under Chinese NMPA license H20234043, and identified by the national product code 86981522000122.
?? For laboratory research only. Not for human or veterinary use.
Sacubitril/Valsartan Sodium Product Specifications
Parameter | Details |
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Product Name | Sacubitril/Valsartan Sodium Tablets (Yixintan) |
Generic Name | Sacubitril and Valsartan Sodium |
CAS Number | 936623-90-4 (Sacubitril), 137862-53-4 (Valsartan) |
Molecular Formula | C24H29NO5 (Sacubitril), C24H29N5O3 (Valsartan) |
Molecular Weight | ~411.5 g/mol (Sacubitril), ~435.5 g/mol (Valsartan) |
Dosage Form | Tablet |
Strength | 100mg per tablet |
Quantity | 14 tablets per box (2 blisters × 7 tablets) |
Approval Number | H20234043 |
Product Code | 86981522000122 |
Manufacturer | Jiangsu Xuantai Pharmaceutical Co., Ltd. |
Storage Conditions | Store below 25°C; avoid moisture and light |
Intended Use | For laboratory research only |
Barcode | 6973355390055 |
Sacubitril/Valsartan Sodium Mechanism & Research Applications
Sacubitril/Valsartan exhibits dual pharmacological action: sacubitril inhibits neprilysin, increasing beneficial peptides like natriuretic peptides, while valsartan blocks angiotensin II receptors, reducing vasoconstriction and aldosterone release. This synergistic effect reduces blood pressure and improves cardiac remodeling.
Research applications include:
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Laboratory models of chronic heart failure (HFrEF)
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Neprilysin inhibition pharmacology
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RAAS modulation and vascular function assays
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Studies in ventricular remodeling and myocardial fibrosis
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Comparative studies with ACE inhibitors and ARBs
Safety & Handling
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Use Restriction: For laboratory research only. Not for therapeutic, diagnostic, or veterinary use.
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Handling Requirements: Use PPE—gloves, safety goggles, and lab coat.
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Storage: Store in a sealed container below 25°C; keep dry and protected from light.
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Disposal: Dispose of according to institutional lab chemical waste procedures.
Research Use Disclaimer
This product is intended exclusively for laboratory research use and is not certified for therapeutic, diagnostic, or veterinary applications. Improper use may pose legal and safety risks. Always follow local biosafety and research compliance protocols.
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