Product Overview

Semaglutide is a long-acting GLP-1 analogue with 94% sequence homology to human GLP-1. This white to off-white powder (Molecular Weight: 4113.58) demonstrates high-affinity binding to GLP-1 receptors (IC50 = 0.38±0.06 nM), making it a valuable compound for metabolic research.

 Key Specifications

• CAS Number: 910463-68-2
• Purity: 98% (HPLC verified)
• Format: Lyophilized powder
• Storage: -80°C long-term (6 months stable at -20°C)
• Shipping: Room temp (continental US) / Cold chain (international)

 Research Applications

1. Type 2 Diabetes Studies

• Mimics endogenous GLP-1 to stimulate insulin secretion
• Demonstrated plasma half-life of 46h in mini-pig models [1]

2. Neuroprotective Effects

• Rescues tyrosine hydroxylase (TH) levels in dopaminergic neurons [2]
• Reduces neuroinflammation and lipid peroxidation

3. NAFLD/NASH Research

• Currently in Phase 2 clinical trials for non-alcoholic steatohepatitis (NCT03987074)

 Technical Data

In Vitro Performance

• 94% sequence homology to human GLP-1
• Derivatized at Lys26 for enhanced stability
• Binds GLP-1R with higher affinity than native GLP-1

In Vivo Observations (Mini-Pig Model)

Data from peer-reviewed studies [1][2]. MCE has not independently verified these findings.

Important Notes

• Research Use Only – Not for human or veterinary diagnostic/therapeutic use
• Storage: Maintain sealed at -80°C for long-term preservation
• Handling: Use PPE when reconstituting (avoid moisture exposure)

Ordering Information

• Pack Size: 1mg, 5mg, 10mg (custom quantities available)
• Shipping:
  • USA: 2-3 business days (UPS/FedEx)
  • International: 5-7 days (DHL Express with cold pack)
• COA: Provided with all orders

Why Researchers Choose Us

• Batch-specific purity testing
• Same-day shipping (orders before 3pm EST)
• SDS & technical documents included
• Discreet packaging for academic labs

Keywords 

• “Buy Semaglutide powder CAS 910463-68-2”
• “GLP-1 receptor agonist for research”
• “Semaglutide vs Liraglutide in vitro”
• “Type 2 diabetes research compounds”
• “High-purity Semaglutide supplier”

Note: This product is NOT for human consumption. Compliance with all local regulations is the buyer’s responsibility.