Sodium Phenylbutyrate Granules – For Research Use Only

Description

Sodium phenylbutyrate (NaPB) is a nitrogen-scavenging agent used to treat urea cycle disorders by converting glutamine into phenylacetylglutamine for renal excretion. Its granule form is coated to mask odor and improve patient compliance. It also functions as a histone deacetylase inhibitor and chemical chaperone in research contexts. In laboratory models, it supports studies on ammonia detoxification, enzyme dysregulation, metabolic stability, and possible neurological and protein-folding mechanisms. Taste?masked granule formulation improves palatability and experimental usability. For laboratory research use only.

Product Specifications

Mechanism of Action & Research Applications

Sodium Phenylbutyrate acts as an ammonia scavenger by being metabolized to phenylacetylglutamine, which is excreted instead of urea. It also serves as a histone deacetylase inhibitor and chemical chaperone. Research applications include modeling urea cycle disorders, hyperammonemia clearance, HDAC-inhibition pathways, protein-misfolding studies (e.g. cystic fibrosis), and neuroprotective experiments.

Side Effects (For Reference Only in Research Models)

Based on clinical observations, reported effects include mild gastrointestinal symptoms, body odor, menstrual irregularities, headache, and occasional neurotoxicity at high doses. These inform experimental safety monitoring and dose-titration studies.

Disclaimer

Sodium Phenylbutyrate Granules are strictly intended for laboratory research use only. Not for human or veterinary therapeutic, diagnostic, or prophylactic application.