描述
Ziprasidone Mesylate is a second-generation atypical antipsychotic and serotonin-dopamine receptor antagonist (SDRA), with high affinity for 5-HT2A and D2 receptors. It is frequently used in experimental models for psychotic disorders, receptor-binding studies, and central nervous system (CNS) drug testing.
Product Specifications
Parameter | Details |
---|---|
Product Name | Ziprasidone Mesylate for Injection |
Generic Name | Ziprasidone Mesylate |
CAS Number | 138982-67-9 |
Molecular Formula | C21H21ClN4OS·CH4O3S |
Molecular Weight | ~516.99 g/mol |
Formulation | Lyophilized powder for injection |
Strength | 10?mg per 1?ml |
Pack Size | 2 vials per box |
Approval Number | H20060346 (NMPA, China) |
Drug Code | 86901034000069 |
Manufacturer | Chongqing Shenghuaxi Pharmaceutical Co., Ltd. |
Product Barcode | 6933982500142 |
Storage Conditions | Store below 25?°C, avoid light and moisture |
Intended Use | For laboratory research purposes only |
Mechanism of Action
Ziprasidone acts as a serotonin 5-HT2A antagonist and dopamine D2 receptor antagonist, exhibiting a balanced SDRA (serotonin-dopamine receptor antagonist) profile. It also inhibits serotonin/norepinephrine reuptake, making it highly suitable for multimodal psychiatric research.
Research Applications
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Schizophrenia and Bipolar Disorder Models
Used in rodent and primate studies to simulate antipsychotic efficacy and behavioral modulation. -
Receptor-Binding Assays
Valuable in receptor affinity and binding site kinetic profiling. -
Neurotransmitter Interaction Studies
Useful in studies involving serotonergic and dopaminergic transmission. -
Long-term CNS Safety Models
For assessing motor function, metabolic effects, and extrapyramidal symptoms.
Handling & Storage
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Handling: Use PPE; reconstitute aseptically with sterile water for injection.
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Stability: Store at 2–8?°C after reconstitution; stable as dry powder up to 24 months.
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Safety: Avoid inhalation/contact. For research staff use only.
Research-Use Disclaimer
This product is sold strictly for laboratory research and experimental use only. It is not for human, diagnostic, therapeutic, or veterinary application. Any misuse may pose health hazards. Always follow biosafety and handling protocols.
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