Fluorouracil 0.25?g – Pyrimidine Antimetabolite for Cancer Research

$1.00

Fluorouracil (5-FU) Injection (0.25?g per vial, 10 vials/box; approval H20051137; code?86901890000968; barcode?6921329400538), manufactured by Yuanda Feiyun Pharmaceutical Co., Ltd. It is a potent pyrimidine antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis and used extensively in preclinical tumor models. Strictly for laboratory research?Please consult the staff for other purposes?

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描述

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1 Fluorouracil Product Specifications

2 Fluorouracil Mechanism of Action

3 Research & Pharmacology Context

4 Research Applications

Fluorouracil Product Specifications

Attribute	Details
Product Name	Fluorouracil Injection
Strength	0.25?g per vial
Quantity	10 vials
Dosage Form	Sterile solution for injection
Approval Number (NMPA)	H20051137
Product Code	86901890000968
Manufacturer	Yuanda Feiyun Pharmaceutical Co., Ltd.
Bar Code	6921329400538
Mechanism Class	Pyrimidine antimetabolite (TS inhibitor)
Intended Use	Laboratory research only — not for clinical or veterinary use

Fluorouracil Mechanism of Action

5-Fluorouracil mimics uracil and incorporates into RNA/DNA; more importantly, it inhibits thymidylate synthase (TS), causing a “thymineless death” in rapidly proliferating cells.

Research & Pharmacology Context

Widely used in preclinical models of colorectal, breast, gastric, and pancreatic cancers .
Several dosing strategies are utilized in vitro and in vivo, including bolus and continuous infusion regimens analogous to clinical protocols drugs.com.
Key toxicities include myelosuppression, mucositis, diarrhea, cardiotoxicity, hand-foot syndrome, and neurologic effects .

Research Applications

Preclinical tumor models (colon, breast, gastric, pancreatic)
Mechanistic studies of thymidylate synthase inhibition and DNA damage
Combination therapy research (e.g., with SN-38 or cisplatin)
Pharmacogenetic assessments (e.g., DPD variations) pubmed.ncbi.nlm.nih.gov+4zh.wikipedia.org+4drugs.com+4

?? Research?Use Only Disclaimer

This product is strictly for laboratory research and development use. Not for clinical, diagnostic, therapeutic, or veterinary use.

其他信息

重量	1.1 公斤
尺寸	18 × 18 × 16 厘米

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How does Fluorouracil work?

Inhibits thymidylate synthase and disrupts DNA/RNA synthesis, leading to cell death in dividing cells.

What models is it commonly used in?

Models of colorectal, breast, gastric, and pancreatic cancers, both in vitro and in vivo.

What are key precautions?

Handle as cytotoxic. Monitor for cytotoxic effects in cell assays. Adhere to biosafety standards.

Are COA/SDS documents available?

Yes — available upon request for qualified research institutions.