Description

Product Description

Selinexor (CAS 1393477-72-9) is a small-molecule selective inhibitor of nuclear export (SINE) that covalently binds to the nuclear export protein XPO1/CRM1, preventing transport of key tumor suppressor proteins and regulatory molecules from the nucleus to the cytoplasm. By blocking nuclear export, Selinexor restores the nuclear localization of tumor suppressors, triggers cell cycle arrest, and induces apoptosis in cancer cells.

Physical and Chemical Properties:

• Molecular formula: C18H12F6N6O

• Molecular weight: 443.31 g/mol

• Appearance: White to off-white crystalline powder

• Solubility: Soluble in DMSO, ethanol; low aqueous solubility

• Stability: Stable at 2–8 °C; protect from light and moisture

Research Applications:

1. Nuclear Export Inhibition: Studying XPO1-mediated nuclear transport and subcellular localization of tumor suppressors (p53, p21, FOXO3a).

2. Apoptosis and Cell Cycle Studies: Induces apoptosis through activation of caspases, mitochondrial pathway, and G1/G2 cell cycle arrest.

3. Anticancer Mechanistic Research: Useful in understanding transcriptional regulation, oncogenic pathway modulation, and tumor suppressor function restoration.

4. Drug Resistance Modeling: Evaluates resistance mechanisms related to nuclear transport, compensatory signaling, and combination therapy sensitization.

5. Combination Therapy Research: Investigates synergy with chemotherapy, targeted inhibitors, and immunotherapeutics in preclinical models.

6. In vivo Studies: Suitable for xenograft tumor models, pharmacokinetic/pharmacodynamic evaluation, and assessment of nuclear export inhibition in tissues.

7. Molecular Mechanistic Research: Studies intracellular signaling, apoptosis pathways, transcription factor nuclear retention, and cytoplasmic-to-nuclear ratio dynamics.

Experimental Considerations:

• Handling: Powder should be handled with gloves, lab coat, and eye protection.

• Dosing: Concentrations vary based on cell type and experimental design.

• Solvent Compatibility: Dissolve in DMSO or ethanol before dilution in culture media.

• Storage: Store at 2–8 °C; avoid repeated freeze-thaw cycles and prolonged light exposure.

Selinexor’s high selectivity for XPO1, robust nuclear export inhibition, and high purity (≥99%) make it a critical reagent for mechanistic cancer research, apoptosis studies, and transcriptional regulation investigations.

Product Specifications

Mechanism of Action

Selinexor is a selective inhibitor of nuclear export (SINE) that targets XPO1/CRM1, a key nuclear export protein responsible for transporting tumor suppressor proteins, growth regulatory factors, and transcription factors from the nucleus to the cytoplasm. By covalently binding to cysteine 528 in XPO1, Selinexor prevents nuclear export, leading to accumulation of tumor suppressors in the nucleus, disruption of oncogenic signaling, and induction of apoptosis.

Key Molecular Mechanisms:

1. Nuclear Retention of Tumor Suppressors: Selinexor promotes nuclear accumulation of p53, p21, FOXO3a, IκB, and other regulatory proteins, restoring their transcriptional activity and enhancing anticancer responses.

2. Apoptosis Induction: Nuclear retention triggers caspase activation, mitochondrial membrane depolarization, and modulation of Bcl-2 family proteins, leading to intrinsic apoptotic pathway activation.

3. Cell Cycle Arrest: Inhibits progression through G1 and G2 phases, mediated by restoration of nuclear cyclin-dependent kinase inhibitors and checkpoint regulators.

4. Transcriptional Regulation: By retaining transcription factors in the nucleus, Selinexor modulates expression of genes involved in cell survival, proliferation, and DNA damage response.

5. Drug Resistance and Mechanistic Studies: Serves as a model for understanding nuclear transport-dependent resistance, combination therapy sensitization, and evaluation of XPO1-related signaling networks.

Experimental Applications:

• In vitro: Quantify nuclear vs. cytoplasmic localization of tumor suppressors, assess apoptosis markers, cell cycle distribution, and transcriptional changes.

• In vivo: Xenograft tumor models, pharmacokinetic/pharmacodynamic analysis, and evaluation of nuclear export inhibition in tissues.

• Combination Therapy Research: Explore synergistic effects with chemotherapy, targeted agents, or immunomodulators.

• Mechanistic Studies: Investigation of XPO1-dependent transcriptional regulation, apoptotic pathway activation, and subcellular protein distribution.

Selinexor’s selectivity for XPO1, reproducible nuclear retention effects, and high purity (≥99%) make it a critical tool for mechanistic cancer research and drug resistance studies.

Side Effects

Selinexor is a research-grade compound; laboratory handling requires standard safety precautions:

• Cytotoxicity: Induces apoptosis and growth arrest in sensitive cell lines, with effects concentration- and time-dependent.

• Handling Safety:

  • Use gloves, lab coat, and eye protection.

  • Handle in fume hoods or biosafety cabinets if dust or aerosol formation is possible.

• Storage: Store at 2–8 °C; protect from light and moisture; avoid repeated freeze-thaw cycles.

• Environmental Safety: Dispose of residual powder and contaminated materials according to institutional safety protocols.

Experimental Observations:

• In vitro: Nuclear accumulation of tumor suppressors, cell cycle arrest, caspase activation, apoptosis.

• In vivo: Tumor growth inhibition, nuclear export blockade, and pharmacodynamic effects on XPO1-regulated proteins.

Keywords

Selinexor, CAS 1393477-72-9, SINE compound, XPO1 inhibitor, nuclear export inhibitor, apoptosis induction, cell cycle arrest, transcriptional regulation, tumor suppressor nuclear retention, high purity, ≥99% purity, factory peptide/small-molecule supplier, peptide wholesale China, China peptide manufacturer, OEM & bulk peptide production.

Shipping Guarantee

All Selinexor shipments are handled via validated cold-chain logistics to maintain chemical stability. The powder is sealed in moisture- and light-protected containers with secondary packaging. Full tracking, insurance coverage, and international courier support ensure secure delivery.

Trade Assurance

Selinexor authenticity is guaranteed, with ≥99% purity verified by HPLC, MS, and NMR. Each batch includes a Certificate of Analysis (CoA). Trade assurance covers replacement or refund for any deviation from listed specifications, ensuring reliable high-purity product for research use.

Payment Support

Secure global payment options: PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are encrypted and verified for confidentiality and fund protection.

Disclaimer

This product is intended for laboratory research use only. It is not for human or veterinary administration. Researchers must follow institutional safety protocols. Data generated with Selinexor should not be interpreted as clinical or therapeutic guidance.

References

1. PubChem: Selinexor (CID 54769923)  ↗

2. ChEMBL: Selinexor Bioactivity (ChEMBL ID CHEMBL3825052)  ↗

3. DrugBank: Selinexor – DB14761  ↗

4. PubMed ID 27882712 – Selinexor mechanism and preclinical studies  ↗

5. IUPHAR/BPS Guide to Pharmacology: XPO1 inhibitors  ↗