Description

Product Description

Mesna (sodium 2-mercaptoethanesulfonate) is a synthetic low-molecular-weight thiol compound designed for experimental investigation of cytoprotective and detoxifying mechanisms. In laboratory research, Mesna functions as a nucleophilic scavenger of reactive electrophilic species, supporting studies on oxidative stress, reactive oxygen species (ROS), and chemoprotective pharmacology.

Key experimental applications include:

• Chemoprotective research: Examining thiol-mediated neutralization of reactive metabolites in preclinical models.

• Oxidative stress studies: Investigating cellular responses to ROS and free radicals, and the role of thiol antioxidants.

• Detoxification pathway research: Studying sulfhydryl-mediated conjugation and detoxification of reactive intermediates.

• Combination experiments: Evaluating synergistic cytoprotective effects with other small molecules, enzyme modulators, or antioxidants.

• Pharmacokinetic and mechanistic studies: Modeling absorption, distribution, metabolism, and excretion in laboratory systems.

Mesna is supplied as a high-purity crystalline powder, typically ≥99%, suitable for solution preparation, in vitro assays, and preclinical studies. Its solubility in water, DMSO, and ethanol allows flexible experimental application. Analytical verification using HPLC, MS, and NMR ensures reproducibility and suitability for mechanistic studies in chemical biology, pharmacology, and toxicology.

Due to its nucleophilic thiol group, Mesna is widely used as a model compound for studying sulfhydryl-dependent detoxification, conjugation reactions, and free radical scavenging. Its small-molecule properties and chemical stability make it a reliable tool for laboratory investigation of chemoprotective mechanisms and cellular redox modulation.

Product Specifications

Mechanism of Action

Mesna acts as a nucleophilic thiol that neutralizes reactive electrophilic species generated in chemical and biological systems. Its mechanism of action in laboratory research involves conjugation of reactive metabolites and scavenging of free radicals to prevent cellular damage.

Thiol-Mediated Detoxification

Mesna’s sulfhydryl group binds electrophilic intermediates, forming stable conjugates that are more easily excreted or metabolized in experimental models. This property allows researchers to study detoxification mechanisms and reactive metabolite neutralization.

Oxidative Stress Modulation

By scavenging ROS and free radicals, Mesna modulates intracellular redox status. Laboratory studies investigate its effects on oxidative damage markers, antioxidant enzyme activity, and cytoprotection in cell and animal models.

Experimental Applications

• In vitro cytoprotection assays against electrophilic stress

• Reactive oxygen species modulation studies

• Sulfhydryl conjugation and detoxification pathway research

• Combination studies with other antioxidants or small molecules

• Pharmacokinetic and mechanistic modeling in preclinical systems

Mesna’s high selectivity for reactive electrophiles and chemical stability make it an ideal tool for studying chemoprotective mechanisms, oxidative stress, and detoxification pathways in laboratory research.

Side Effects

In experimental studies, Mesna exhibits minimal cytotoxicity at recommended concentrations. Observed effects may include transient modulation of redox-sensitive signaling pathways or cellular responses in vitro or in vivo. Mesna is not intended for clinical use outside controlled laboratory research.

Keywords

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Shipping Guarantee

All Mesna shipments of Mesna are handled using validated cold-chain and protective packaging logistics to maintain chemical integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage to ensure safe and timely delivery.

Trade Assurance

We guarantee the authenticity and high purity (≥99%) of Mesna. Each batch undergoes strict analytical verification using HPLC, MS, and NMR to confirm identity, purity, and structural integrity. A Certificate of Analysis (CoA) is provided with each batch. Our trade assurance policy ensures replacement or refund for any deviation from listed specifications.

Payment Support

We Mesna provide secure and flexible payment options for global research transactions, including PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are encrypted and verified, ensuring confidentiality and protection of funds.

Disclaimer

All Mesna products are intended for laboratory research use only. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must adhere to institutional biosafety and chemical safety guidelines. Information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.