Description
Tenofovir Amibufenamide is a nucleotide analog reverse transcriptase inhibitor (NtRTI) prodrug, developed for its high liver-targeting efficiency and improved safety profile over traditional tenofovir-based agents. It is commonly studied in preclinical models of chronic hepatitis B virus (HBV) infection due to its potent suppression of viral DNA replication with lower systemic toxicity.
This formulation offers enhanced pharmacokinetic characteristics, better intracellular activation, and reduced renal and bone toxicity markers, making it ideal for comparative studies of antiviral drug development.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Tenofovir Amibufenamide Tablets (Hengmu) |
| Generic Name | Tenofovir Amibufenamide |
| Chemical Class | NtRTI (Nucleotide Reverse Transcriptase Inhibitor) |
| CAS Number | [To be verified; likely similar to Tenofovir-related compounds] |
| Molecular Formula | C21H28N5O6P (tentative) |
| Molecular Weight | ~ 477.45 g/mol |
| Strength | 25?mg per tablet |
| Quantity per Box | 28 tablets (film-coated) |
| Form | Oral tablets |
| Dosage Form | Tablet |
| Approval Number | H20210029 (China NMPA) |
| Product Code | 86983096000010 |
| Manufacturer | Changzhou Hengbang Pharmaceutical Co., Ltd. |
| Barcode | 6924647728315 |
| Storage | Store below 25?°C, keep in a dry place away from light |
| Intended Use | Laboratory research only |
Mechanism of Action
Tenofovir Amibufenamide is converted intracellularly into tenofovir diphosphate, which inhibits HBV reverse transcriptase by competing with natural substrates and causing DNA chain termination. It exhibits superior hepatic distribution and activation compared to traditional tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF).
Research Applications
Chronic hepatitis B (CHB) suppression studies
NtRTI comparative efficacy and toxicity models
Hepatic targeting and drug activation pharmacokinetics
In vitro HBV replication inhibition assays
Resistance mutation screening in HBV reverse transcriptase
Safety & Handling
Storage: Room temperature, sealed in original packaging
Handling: Use PPE; avoid inhalation or contact with skin and eyes
Stability: Do not expose to heat or moisture
Warning: Not for therapeutic or diagnostic use in humans or animals
Core Keywords
Tenofovir Amibufenamide Tablets
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Research Use Disclaimer
This product is intended strictly for laboratory research purposes only. It is not for human or animal consumption, nor for diagnostic or therapeutic use. Use only in accordance with appropriate safety protocols and institutional guidelines.


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