描述
Alendronate Sodium is a potent nitrogen-containing bisphosphonate that inhibits farnesyl pyrophosphate synthase in osteoclasts, reducing bone resorption and increasing bone density. Widely used for research in osteoporosis modeling, Paget’s disease, and bone metabolism dynamics. The Kaijian formulation provides a consistent 10?mg dose per tablet, enabling controlled in vitro and in vivo studies on skeletal tissues.
Manufactured by Hainan Kaijian Pharmaceutical Co., Ltd., this product is approved under China’s NMPA registration number H20064818, drug code 86905788000016, barcode 6935642308068. Ideal for preclinical research settings. ?? Not intended for therapeutic use.
Alendronate Sodium Tablets Product Specifications
Parameter | Details |
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Product Name | Alendronate Sodium Tablets (Kaijian) |
Generic Name | Alendronate Sodium |
CAS Number | 121268?17?5 |
Molecular Formula | C?H??NNaO?P?·3H?O |
Molecular Weight | 325.12?g/mol |
Dosage Form | Film-coated oral tablet |
Strength | 10?mg per tablet |
Quantity | 10 tablets per box |
Approval Number | H20064818 (China NMPA) |
Product Code | 86905788000016 |
Manufacturer | Hainan Kaijian Pharmaceutical Co., Ltd. |
Barcode | 6935642308068 |
Storage Conditions | Store sealed at 20–25?°C, away from moisture |
Intended Use | Laboratory research only |
Alendronate Sodium Tablets Mechanism & Research Applications
Alendronate Sodium works by binding to bone hydroxyapatite and inhibiting osteoclast-mediated bone resorption via farnesyl pyrophosphate synthase inhibition. It’s widely used for:
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Osteoporosis and bone density modeling
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Investigating Paget’s disease in preclinical studies
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Bone turnover and remodeling assays
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Muscle–bone interaction models
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Comparative studies with other bisphosphonates
Alendronate Sodium Tablets Side Effects (Research Observations)
Research and clinical data report potential effects such as:
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Gastric and esophageal irritation or ulceration
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Reduced calcium absorption and transient hypocalcemia
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Musculoskeletal discomfort or bone/joint pain
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Rare adverse effects in long-term dosing: osteonecrosis of the jaw, atypical femur fractures
Use proper monitoring and welfare protocols in in vivo models.
Safety & Handling
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Use Restriction: Laboratory research only; not for clinical, therapeutic, or veterinary use
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Handling: Use lab-grade PPE—gloves, lab coat, and eye protection
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Storage: Keep sealed at 20–25?°C, away from moisture
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Disposal: Dispose unused tablets following institutional hazardous waste guidelines
Core Keywords
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Research Use Disclaimer
This product is exclusively for laboratory research use and not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may pose safety or regulatory risks. Always use within authorized institutional biosafety protocols.
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