Description

Product Description 

Cagrilintide is a synthetic amide peptide analog of amylin, developed for research on metabolic regulation, appetite suppression, and glucose homeostasis. Its molecular structure allows it to bind selectively to amylin receptors (AMY1, AMY2, AMY3) in the central nervous system and peripheral tissues, mediating satiety signaling, delayed gastric emptying, and postprandial glucagon suppression. These properties make Cagrilintide an essential tool in preclinical research, particularly for exploring type 2 diabetes, obesity, and other metabolic disorders.

In vitro studies demonstrate that Cagrilintide modulates pancreatic β-cell activity, insulin secretion, and glucose-dependent feedback loops, providing insights into the molecular mechanisms governing energy balance. It also affects hypothalamic neurons involved in appetite regulation, enabling researchers to study neuroendocrine control of feeding behavior, satiety pathways, and peptide-receptor interactions. Its ability to activate downstream signaling cascades such as cAMP-mediated pathways and receptor desensitization supports mechanistic studies of peptide pharmacodynamics and receptor-mediated metabolic control.

Cagrilintide Peptide Powder is manufactured under GMP-grade synthetic protocols, ensuring high purity (≥99%) and reproducibility across experimental batches. Lyophilized powder is stable at 2–8 °C and protected from moisture, light, and repeated freeze-thaw cycles. Each batch undergoes HPLC, mass spectrometry, and endotoxin testing, with full documentation including COA, MSDS, and QC reports. This ensures suitability for in vitro, ex vivo, and in vivo studies, supporting translational and preclinical research.

The peptide’s versatility allows integration into multi-omic workflows, high-throughput screening, organ-on-chip platforms, and 3D tissue models, enabling researchers to explore molecular and physiological effects in physiologically relevant systems. Cagrilintide is particularly useful in studies evaluating combinatorial therapies, synergistic metabolic effects, and novel peptide analogs.

In vivo research applications include administration in rodent models of obesity, diabetes, and metabolic syndrome, where it is used to monitor food intake, body weight, hormone levels, and glycemic responses. Dose-dependent studies provide insights into long-term satiety effects, glucose regulation, and energy expenditure, supporting translational investigations.

Factory production and OEM customization enable cost-effective bulk supply for academic institutions, pharmaceutical companies, and contract research organizations. Its well-characterized effects on metabolic signaling, insulin-glucagon balance, and appetite modulation make it a foundational reagent for metabolic research. High-purity Cagrilintide Peptide Powder ensures reproducible experimental outcomes, robust mechanistic insights, and compatibility with advanced laboratory platforms, making it indispensable for researchers in metabolic disease, appetite regulation, and peptide therapeutic development.

Product Specifications

Notes ：

Cagrilintide is synthesized using GMP-compliant peptide synthesis, ensuring high purity, reproducibility, and biological activity. The lyophilized powder is stable at 2–8 °C, minimizing degradation and facilitating precise reconstitution for research use. HPLC and mass spectrometry confirm peptide identity and purity, while endotoxin testing ensures suitability for in vitro and in vivo studies.

The peptide is highly soluble in sterile water or PBS, allowing accurate preparation of experimental concentrations for studies on glucose regulation, appetite control, pancreatic β-cell activity, and satiety signaling. Its predictable biological activity makes it suitable for integration into multi-omic analysis, high-throughput screening, organ-on-chip platforms, and translational research workflows, supporting robust and reproducible outcomes.

Bulk production with OEM and custom packaging ensures cost-effective supply for academic and industrial laboratories. Each batch is supplied with comprehensive COA, MSDS, and QC documentation, ensuring traceability, regulatory compliance, and consistent performance. Cagrilintide’s well-characterized effects on metabolic pathways, insulin-glucagon balance, and appetite modulation make it a foundational reagent for metabolic research and peptide therapeutic development.

Mechanism of Action 

Cagrilintide is a synthetic amylin analog peptide designed to mimic the physiological actions of endogenous amylin, a hormone co-secreted with insulin by pancreatic β-cells. Its mechanism of action involves binding to amylin receptors (AMY1, AMY2, AMY3) in the central nervous system and peripheral tissues, modulating satiety, gastric emptying, and glucose homeostasis. By activating these receptors, Cagrilintide slows gastric emptying, suppresses postprandial glucagon secretion, and promotes a sense of fullness, which is critical for appetite regulation and energy balance studies.

In metabolic research models, Cagrilintide influences pancreatic β-cell function, supporting insulin secretion and modulating the insulin-to-glucagon ratio. These effects contribute to improved glycemic control, particularly in preclinical studies on type 2 diabetes and obesity. The peptide’s action on central nervous system pathways also reduces caloric intake by activating anorexigenic neurons in the hypothalamus and brainstem.

At the molecular level, Cagrilintide impacts cAMP-mediated signaling, gene expression of metabolic regulators, and receptor desensitization pathways. These cellular effects facilitate detailed investigations into energy homeostasis, satiety mechanisms, and peptide-based therapeutic interventions. Additionally, its structural stability and high receptor affinity allow researchers to evaluate dose-dependent responses, pharmacokinetics, and pharmacodynamics in both in vitro and in vivo models.

Cagrilintide is compatible with high-throughput screening, organ-on-chip platforms, and multi-omic analyses, providing insights into downstream effects on gene expression, protein signaling, and metabolic pathways. Its predictable activity enables reproducible experimental outcomes across different research models, supporting mechanistic studies, drug discovery, and preclinical therapeutic development.

Overall, Cagrilintide serves as a versatile and robust tool for laboratory research on glucose regulation, appetite control, metabolic disease mechanisms, and peptide therapeutics. By combining receptor-mediated satiety effects, modulation of pancreatic β-cell activity, and downstream metabolic signaling, Cagrilintide provides researchers with a reliable reagent for understanding complex metabolic pathways and advancing translational research in metabolic disorders.

Applications 

Cagrilintide Peptide Powder is primarily utilized in research focused on glucose regulation, appetite control, and metabolic disease mechanisms. In vitro, it is applied to pancreatic β-cell lines, hypothalamic neurons, and gastrointestinal cell cultures to study effects on insulin secretion, glucagon suppression, and satiety signaling pathways. These studies provide critical insights into metabolic homeostasis, energy balance, and peptide-based therapeutic mechanisms.

In vivo, Cagrilintide is commonly used in rodent models of obesity, type 2 diabetes, and metabolic syndrome. Researchers administer the peptide to evaluate its effects on food intake, body weight, glycemic control, and hormone modulation. These models allow for the examination of both short-term and long-term physiological responses, including postprandial glucose regulation, appetite suppression, and energy expenditure.

Cagrilintide is also compatible with organ-on-chip systems and 3D tissue models, enabling mechanistic studies of metabolic regulation in a physiologically relevant environment. Integration into these advanced models allows for analysis of cellular signaling, receptor activity, and hormone interactions, providing a deeper understanding of metabolic disease pathways.

Additionally, Cagrilintide is used in multi-omic studies, including transcriptomics, proteomics, and metabolomics, to investigate molecular effects on gene expression, protein signaling, and metabolite profiles. This facilitates a comprehensive evaluation of peptide-mediated metabolic changes and supports drug discovery, pharmacological testing, and translational research.

High-purity, GMP-grade Cagrilintide supports reproducible outcomes, allowing researchers to explore mechanistic pathways of energy balance, appetite regulation, and peptide therapeutics with precision. Bulk supply and OEM customization make it suitable for both academic and industrial research programs.

Overall, Cagrilintide serves as a versatile research reagent for studying metabolic disease, glycemic control, appetite regulation, and peptide-based interventions, supporting both mechanistic investigations and translational applications in laboratory research.

Research Models 

Cagrilintide Peptide Powder is widely employed in in vitro and in vivo research models to investigate glucose regulation, appetite control, and metabolic disease mechanisms. In vitro, it is applied to pancreatic β-cell cultures, hypothalamic neurons, and enteroendocrine cells to examine effects on insulin secretion, glucagon suppression, satiety hormone signaling, and cellular energy metabolism. These studies provide detailed insights into the molecular pathways influenced by Cagrilintide, including cAMP-mediated signaling and receptor desensitization.

In vivo, Cagrilintide is used in rodent models of obesity, type 2 diabetes, and metabolic syndrome. Researchers monitor food intake, body weight, blood glucose levels, and hormone profiles to assess peptide efficacy. Rodent studies also allow investigation of long-term metabolic effects, appetite regulation, and energy homeostasis, enabling translational insights for potential peptide-based therapies. Careful dosing and time-course studies ensure reproducible and physiologically relevant outcomes.

Cagrilintide is compatible with advanced tissue models, such as organ-on-chip platforms and 3D cultures, allowing mechanistic studies under physiologically relevant conditions. These systems support analysis of cellular signaling pathways, hormone interactions, and tissue-level metabolic responses, providing a bridge between in vitro and in vivo research.

Moreover, Cagrilintide is suitable for multi-omic integration, including transcriptomics, proteomics, and metabolomics, allowing comprehensive evaluation of molecular changes in response to peptide treatment. Data generated from these models can inform computational modeling, pathway analysis, and predictive studies of metabolic regulation.

Overall, Cagrilintide Peptide Powder is a versatile and reliable reagent for mechanistic studies, preclinical research, and translational investigations into metabolic disease, appetite regulation, and peptide therapeutics, supporting reproducible outcomes across diverse research models.

Experimental Design Considerations 

When designing experiments with Cagrilintide Peptide Powder, careful attention to dose, exposure duration, and model selection is essential for reproducible and meaningful results. In cell-based assays, peptide concentrations should be optimized to stimulate insulin secretion, glucagon suppression, and satiety signaling without causing cytotoxicity. Time-course studies are recommended to capture both immediate responses, such as cAMP signaling activation, and longer-term gene expression changes related to metabolic regulation.

For in vivo studies, appropriate dosing must consider species-specific metabolism, tissue distribution, and peptide stability. Rodent models often use subcutaneous or intraperitoneal administration, with monitoring of food intake, body weight, blood glucose, and hormone levels. Multiple time points allow evaluation of short-term satiety effects and long-term metabolic regulation, ensuring accurate characterization of peptide activity.

Integration with multi-omic analyses requires careful coordination of peptide administration, tissue collection, and sample preparation to generate reliable datasets. Transcriptomic, proteomic, and metabolomic studies can reveal molecular mechanisms underlying glucose homeostasis, appetite control, and energy balance, supporting translational research applications.

For high-throughput or pharmacological screening, Cagrilintide serves as a reference peptide to benchmark novel compounds or peptide analogs. Proper reconstitution, aliquoting, and storage (2–8 °C for lyophilized powder) are essential to maintain stability and biological activity. Consider potential interactions with buffers, solvents, or co-administered compounds, as these may affect peptide efficacy or assay outcomes.

Overall, meticulous experimental design using Cagrilintide Peptide Powder—including dose optimization, timing, model selection, and multi-omic integration—maximizes reproducibility, data quality, and relevance in studies of metabolic disease, appetite regulation, and peptide-based therapeutics.

Laboratory Safety & Handling Guidelines 

Handling Cagrilintide Peptide Powder requires standard laboratory safety procedures to maintain peptide integrity and ensure researcher safety. Although Cagrilintide is a research-grade peptide and not classified as hazardous, personal protective equipment (PPE) such as gloves, lab coats, and eye protection should be worn. Handling should be performed in designated, clean laboratory areas, and aerosolization should be avoided to prevent contamination.

Lyophilized Cagrilintide should be stored at 2–8 °C, protected from moisture, light, and repeated freeze–thaw cycles to preserve stability and biological activity. Upon reconstitution in sterile water or buffer, aliquots should be prepared to minimize repeated handling. Proper labeling of peptide name, batch number, concentration, and storage conditions ensures traceability and regulatory compliance.

Researchers should avoid exposure to strong acids, bases, or oxidizing agents, which may degrade the peptide or affect its activity. Laboratory surfaces, pipettes, and tools should be regularly decontaminated, and all waste should be disposed of following institutional bioactive peptide protocols. For in vivo studies, proper animal handling, injection safety, and monitoring of physiological responses are essential to maintain reproducibility and animal welfare.

Cagrilintide may affect cellular hormone signaling, energy metabolism, and appetite-regulating pathways. Personnel should be trained in proper pipetting, reconstitution, and handling techniques to prevent experimental variability. Adherence to these safety and handling guidelines ensures consistent experimental results, maintains peptide stability, and complies with institutional and regulatory standards.

Integration with Multi-Omic & Computational Studies 

Cagrilintide Peptide Powder is highly compatible with multi-omic and computational research approaches for investigating metabolic regulation, appetite control, and glucose homeostasis. In transcriptomic studies, Cagrilintide-treated pancreatic β-cells, hypothalamic neurons, or enteroendocrine cells can reveal gene expression changes associated with insulin secretion, glucagon suppression, and satiety signaling pathways. These transcriptional profiles can be correlated with proteomic and metabolomic data to construct a comprehensive picture of peptide-induced cellular effects.

In proteomic studies, Cagrilintide facilitates the analysis of signaling proteins, receptor activation, and post-translational modifications in metabolic pathways. Metabolomic analysis complements these studies by revealing changes in glucose utilization, lipid metabolism, and energy homeostasis following peptide exposure. Integration of these datasets enables researchers to map complex signaling networks and metabolic pathways influenced by Cagrilintide.

Cagrilintide is also suitable for computational modeling and systems biology approaches, where multi-omic data can be used to simulate receptor-mediated satiety signaling, pancreatic β-cell activity, and energy balance regulation. These models can predict dose-response effects, optimize experimental design, and identify potential interactions with other metabolic compounds.

Additionally, Cagrilintide can be incorporated into high-throughput screening platforms, organ-on-chip systems, and 3D tissue models, allowing evaluation of peptide activity in physiologically relevant contexts. The peptide’s high purity and reproducibility support integration across diverse experimental workflows, enabling robust mechanistic studies and translational research in metabolic disorders.

Overall, combining Cagrilintide with multi-omic analyses and computational modeling allows researchers to gain system-level insights into glucose homeostasis, appetite regulation, and peptide-based therapeutics, supporting advanced research and potential preclinical applications.

Keywords

Cagrilintide, metabolic peptide, high-purity peptide, GMP-grade peptide, appetite regulation, glucose control, insulin secretion, glucagon suppression, energy balance, peptide research, OEM peptide, laboratory research, peptide powder wholesale

Shipping Guarantee 

All shipments of Cagrilintide Peptide Powder utilize temperature-controlled packaging (2–8 °C) with moisture protection to ensure peptide stability and biological activity. Tamper-evident containers and secure handling preserve product integrity during transit. Each order includes tracking, batch documentation, and quality verification to guarantee reproducible delivery. Global shipping is optimized for safe and timely arrival at research laboratories.

Trade Assurance 

Factory-direct supply guarantees high-purity, GMP-grade Cagrilintide with consistent batch quality. Bulk quantities, OEM customization, and custom packaging are available to meet diverse research requirements. Each shipment is accompanied by COA, MSDS, and QC documentation, ensuring traceability and regulatory compliance. Researchers can rely on secure procurement with guaranteed product quality and on-time delivery.

Payment Support 

We provide multiple secure international payment options, including bank transfer, corporate credit, PayPal, major credit cards, and cryptocurrency for eligible customers. Bulk, multi-unit, and OEM orders can benefit from flexible payment arrangements tailored to institutional or commercial research projects. All transactions are fully documented to ensure transparency, traceability, and compliance. Our systems are designed for efficient and reliable global procurement of high-purity research peptides.

Disclaimer 

Cagrilintide Peptide Powder is intended for laboratory research use only. It is not for human or veterinary use, clinical applications, or consumption. Users must adhere to institutional biosafety and regulatory protocols when handling this peptide. All experimental applications should be confined to controlled laboratory settings in accordance with local laws and safety standards.

References 

1. PubChem – Cagrilintide
   Chemical and structural information for Cagrilintide.

2. NCBI Bookshelf – Amylin Analogs and Metabolic Regulation
   Overview of amylin analog peptides and their metabolic effects.

3. ScienceDirect – Cagrilintide in Preclinical Studies
   Research articles on metabolic peptide mechanisms.

4. UniProt – Amylin Receptors
   Protein interactions and receptor pathways related to Cagrilintide.

5. RCSB Protein Data Bank – Amylin Peptide Complexes
   Structural data for peptide-receptor interactions.