Tacrolimus Capsules PROGRAF®) 1?mg – For Laboratory Research Use Only

$1.00

PROGRAF® Tacrolimus Capsules are 1?mg each, supplied in a 100?capsule bottle. Produced under license from Astellas Ireland and packaged by Astellas China, approved by NMPA under J20150102. Intended exclusively for laboratory research use; wholesale and retail supported.?For wholesale prices, other specifications and uses, please consult our staff?

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描述

Tacrolimus is a potent calcineurin?inhibitor immunosuppressant used extensively in research to study T?lymphocyte activation, cytokine regulation, and transplant rejection models. Originally derived from Streptomyces tsukubaensis, tacrolimus binds FKBP?12 to inhibit calcineurin, reducing IL?2 and other cytokines, thus suppressing T-cell mediated immune responses.

These capsules are the PROGRAF®-branded formulation, each containing 1?mg tacrolimus. Manufactured by Astellas Ireland Co. Ltd and packaged in China by Astellas, under NMPA approval number J20150102. Not intended for clinical use—strictly for laboratory research.

Contents hide

1 Product Specifications

2 Mechanism of Action & Research Applications

3 Side Effects (For Reference Only in Experimental Models)

4 Disclaimer

Product Specifications

Parameter	Details
Product Name	Tacrolimus Capsules (PROGRAF®)
Generic Name	Tacrolimus
CAS Number	104987-11-3
Molecular Formula	C44H69NO12·H?O
Molecular Weight	822.03?g/mol
Dosage Form	Oral capsules
Strength	1?mg per capsule
Quantity per Bottle	100 capsules
Approval Number	J20150102 (China NMPA)
Manufacturer	Astellas Ireland Co. Ltd.; packaged in China
Barcode	Not recorded; contact online pharmacist
Intended Use	Laboratory research only
Storage Conditions	Store in a cool, dry place below 25?°C

Mechanism of Action & Research Applications

Tacrolimus works by forming a complex with FKBP?12, which then inhibits calcineurin phosphatase activity. This action prevents NF?AT and NF??B activation and suppresses cytokine production such as IL?2, IL?4, IL?6, TNF??, and interferon??.

In laboratory research, tacrolimus capsules are used to:

Model transplant rejection and prevention
Study T-lymphocyte activation and signaling pathways
Evaluate immunosuppressive effects in cell or animal models
Investigate cytokine regulation and immune modulation

Side Effects (For Reference Only in Experimental Models)

In controlled research settings, tacrolimus may cause:

Suppression of T-cell activation
Altered cytokine expression
Potential nephrotoxicity or neurotoxicity at high exposures
Dose-dependent effects on systemic metabolism

These are experimental observations and not indicative of clinical safety.

Disclaimer

Tacrolimus Capsules (PROGRAF®) are for laboratory research use only and not intended for human or veterinary therapeutic use. Use must adhere to institutional biosafety and research safety protocols.

其他信息

重量	1 公斤
尺寸	26 × 23 × 26 厘米

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