Zamerovimab and Mazorelvimab Injection – Wholesale & Retail (For Research Use Only)

描述

Kreibi Injection combines two humanized IgG1? monoclonal antibodies—Zamerovimab and Mazorelvimab—in equal mass ratio, each targeting distinct non-overlapping glycoprotein epitopes on rabies virus. This configuration provides broad-spectrum neutralization, rapid onset of protection, and reduces risk of viral escape. In recent Phase III and preclinical studies, Kreibi achieved rapid induction of rabies virus neutralizing antibodies (RVNA), reaching protective levels (??0.5?IU/mL) as early as Day?1 with higher concentrations than conventional immune globulins. Kreibi is used in research to simulate post-exposure prophylaxis (PEP), assess dose-response, study pharmacokinetics of neutralizing antibodies, and evaluate cross-strain efficacy. Supplied in single-use 6?mg (2?ml) vials. For lab-based research applications only.

Product Specifications

Mechanism of Action & Research Applications

Zamerovimab and Mazorelvimab bind distinct antigenic sites (glycoprotein site III and conserved G5 epitope) on rabies virus particles, achieving high-affinity neutralization and broad-spectrum coverage of multiple virus strains. In research models, Kreibi swiftly achieves high RVNA levels, surpassing traditional HRIG by Day?1–3, and maintains protective titers for extended durations—up to 99?days. It is ideal for modeling passive immunotherapy, evaluating monoclonal antibody pharmacokinetics, studying viral variant neutralization, and designing PEP protocols.

Side Effects (For Reference Only in Research Models)

Preclinical and trial observations report minimal and transient adverse reactions: mild injection-site discomfort, low-grade fever, headache, and transient immune response markers. No serious systemic toxicity reported. Use these safety data to inform dosage design and monitoring in experimental setups.

Disclaimer

Zamerovimab and Mazorelvimab Injection (Kreibi) is strictly intended for laboratory research use only. Not for human or veterinary diagnostic, therapeutic, or clinical use.