描述
Carboplatin is a second?generation platinum compound that forms DNA crosslinks to inhibit cell division. It offers a more favorable toxicity profile compared to cisplatin. In oncology research, Carboplatin Injection (Qilu) is utilized to model DNA damage response, drug resistance in cancer cells, renal-cleared exposure protocols (via area-under-curve dosing), and combination oncology assays. The product is supplied as 0.1?g freeze?dried powder per vial in packs of six. For laboratory research only.
Product Specifications
Parameter | Detail |
---|---|
Product Name | Carboplatin Injection (Qilu) |
Strength | 0.1?g per vial (lyophilized powder) |
Packaging | 6 vials per box |
Dosage Form | Freeze?dried powder for injection |
Manufacturer | Qilu Pharmaceutical Co., Ltd. |
Approval Number | ???? H10920028 |
Drug Standard Code | 86904021000295 |
Barcode | 6915798003635 |
CAS Number | 41575?94?4 |
Molecular Formula | C?H??N?O?Pt |
Mechanism of Action & Research Applications
Carboplatin induces intra- and inter-strand DNA cross-linking, preventing DNA replication and triggering apoptosis. It is widely used in laboratory research to study tumor cytotoxicity, DNA repair mechanisms, pharmacokinetics modeling (e.g., AUC-based dosing), and drug-resistance assays, including combination chemotherapy protocols. It’s particularly valuable for translation models of platinum chemistry in oncology research.
Side Effects (For Reference Only in Research Models)
Based on clinical-analog data, potential responses include bone marrow suppression (thrombocytopenia, neutropenia, anemia), mild nausea, fatigue, and possible allergic reactions. Carboplatin is notably less nephrotoxic than cisplatin, but caution is advised when designing dosing protocols, especially with renal clearance considerations.
Disclaimer
Carboplatin Injection (Qilu) is strictly intended for laboratory research use only. Not for human or veterinary therapeutic or diagnostic use.
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