DOTATATE (DOTA?(Tyr³)?Octreotate) (CAS: 177943?89?4) – Purity 99.95% | GMP Factory

描述

DOTATATE (DOTA?(Tyr³)?octreotate) is a synthetic eight-amino-acid peptide linked to the macrocyclic chelator DOTA. It binds strongly to somatostatin receptor subtype 2 (SSTR?), frequently overexpressed in neuroendocrine tumors (NETs). When labeled with radionuclides such as gallium?68 (^68Ga), lutetium?177 (^177Lu), or copper?64 (^64Cu), DOTATATE enables high-resolution PET imaging or serves as part of peptide receptor radionuclide therapy (PRRT) drug conjugates.

This research-grade peptide is produced in a GMP-compliant facility, with verified purity ?99.95% by HPLC, ensuring high consistency for research in PET imaging development, radiopharmaceutical design, and receptor-targeted therapy platforms.

For laboratory research use only. Not approved for clinical or therapeutic use.

Product Specifications

Mechanism of Action & Research Applications

DOTATATE targets somatostatin receptor subtype 2 (SSTR?) with high affinity, enabling selective localization in SSTR?-positive tissues. When labeled with radionuclides:

• ^68Ga: used in PET imaging for high-resolution detection of neuroendocrine tumors

• ^177Lu: part of PRRT for therapy of NETs by delivering targeted beta radiation

• ^64Cu: another PET tracer for diagnostic applications

Research Applications:

• PET imaging probe development for neuroendocrine tumors (NETs)

• Preclinical design of peptide receptor radionuclide conjugates (RDCs/PRRT)

• Radiochemistry and dosimetry studies

• SSTR? receptor biology and binding assays

• Radiopharmaceutical formulation research

Side Effects (For Research Reference Only)

In experimental models involving radionuclide-labeled DOTATATE, possible effects include:

• Cellular radiotoxicity from beta or Auger electrons

• Receptor-mediated uptake variability

• Radiation-induced DNA damage in high-dose settings
  These are context?dependent effects within lab models and not for therapeutic extrapolation.

Disclaimer

This peptide is manufactured in a GMP-compliant facility with high purity. It is strictly for laboratory research use only and not for human or veterinary use, nor for diagnosis or therapy.