Description

Dapiglutide (also known as ZP-7570) is an investigational, long-acting peptide designed as a dual agonist of glucagon-like peptide-1 (GLP-1) and peptide-2 (GLP-2) receptors. Engineered for once-weekly subcutaneous administration, it is being developed to harness GLP-1–mediated weight loss benefits while simultaneously leveraging GLP-2’s roles in enhancing intestinal barrier function and reducing low-grade inflammation—making it especially relevant in obesity and gut health research. Manufactured with a high standard of quality (?99.40% purity) under GMP conditions, Dapiglutide provides robust consistency for preclinical and translational science.

Product Category

Dual Receptor Incretin Modulators — peptide-based compounds that agonize GLP-1 and GLP-2 receptors to support both metabolic and gastrointestinal health research.

Product Specifications

Mechanism of Action & Research Applications

Dapiglutide binds GLP-1 and GLP-2 receptors, activating pathways that stimulate insulin secretion, reduce food intake, enhance intestinal mucosal integrity, and modulate inflammation. In murine short bowel models, it significantly improved oral glucose tolerance, reduced intestinal transit, increased villus height and intestinal length, and supported body weight restoration despite no change in diet intake.

Clinical-phase trials highlight its obesity potential: in a 28-week Phase 1b study, Dapiglutide achieved an average body weight reduction of 11.6% with high tolerability and no serious adverse effects.

Side Effects (For Research Context Only)

Mild gastrointestinal events—such as nausea and vomiting—were observed at higher doses, mirroring typical profiles of GLP-1 agonists. No serious adverse effects were reported in the Phase 1b trial cohort.

Logistics Transportation

All packages are shipped with full transportation insurance to ensure safe and timely delivery. We offer 100% compensation for lost, detained, or damaged items during transit.

Disclaimer

Dapiglutide is strictly for laboratory research use only and not approved for clinical, diagnostic, therapeutic, or veterinary applications.