Description

Lysipressin Acetate (aka Lysine vasopressin acetate; CAS No. 83968-49-4) is a naturally occurring nonapeptide hormone—an analog of arginine vasopressin—endogenously found in pigs and some marsupial species. Unlike human ADH, Lysipressin replaces the 8th amino acid with lysine, which preserves antidiuretic function while offering unique receptor interaction profiles .

Biologically, Lysipressin activates adenylate cyclase in target cells, particularly within renal and smooth muscle tissues, mediating its antidiuretic and contractile effects. The peptide is known to induce rabbit urinary bladder smooth muscle contraction and stimulate adenylate cyclase, resulting in elevated intracellular cAMP, a classic second messenger.

Manufactured to 99.84% purity, Lysipressin Acetate is produced under GMP-compliant conditions, ensuring traceability, reproducibility, and high-quality performance. Delivered as a stable, lyophilized powder, it supports a wide range of laboratory applications in renal physiology, vasopressin receptor signaling, smooth muscle pharmacology, and neuroendocrine research.

For laboratory research use only. Not for clinical, diagnostic, or veterinary application.

Product Specifications

Mechanism of Action & Research Applications

Lysipressin exerts its primary effects through vasopressin receptors, particularly V2-type receptors in renal collecting ducts and smooth muscle V1-type receptors. By activating adenylate cyclase, it raises intracellular cAMP, promoting water reabsorption in kidneys and mediating muscle contraction.

Research Applications:

• Renal Physiology & Antidiuretic Signaling: Model tools for aquaporin regulation and fluid balance.

• Smooth Muscle Pharmacology: Investigate vasopressin-mediated contractility using rabbit bladder or similar assays.

• Vasopressin Receptor Pharmacodynamics: Comparative studies on Lysine vs. Arginine analogs.

• Endocrine Signal Transduction: Mapping downstream cAMP-mediated pathways.

• Species-Specific Hormone Biology: Insights into evolutionary physiology across mammals.

Development & Research Background

Lysipressin originated from comparative physiological studies identifying alternate vasopressin analogs in non-human mammals. Notably, pig and marsupial endocrine systems utilize Lysine rather than Arginine at position 8, leading to Lys8-vasopressin formation.

Subsequent receptor cloning revealed species-specific affinities and signaling patterns. Specifically, the Lys8-VP receptor in pigs exhibits selective activation of adenylate cyclase when stimulated by Lysipressin, offering insights into peptide–receptor specificity.

As a synthetic peptide, Lysipressin Acetate enables researchers to probe renal hormone function, explore receptor pharmacology in non-human models, and compare effects with human vasopressin analogs. Its well-characterized efficacy in smooth muscle and antidiuretic assays has cemented its value in academic and pharmacological research.

Side Effects

(For experimental reference only)

• Hypercontractile responses in smooth muscle assays if overdosed—requires careful dose titration.

• Excess antidiuretic effects may cause fluid retention in animal models—monitor renal parameters.

• Species-specific receptor mismatch may yield variable responses—valid comparisons require homologous systems.

Disclaimer

Lysipressin Acetate is supplied strictly for laboratory research purposes only. It is not intended for human, clinical, diagnostic, or veterinary use. Handle using standard laboratory safety protocols, and dispose per institutional guidelines.

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