Description

Product Description

Romurtide (CAS No. 78113-36-7), also referred to as Muroctasin, is a synthetic muramyl dipeptide (MDP) derivative designed as an immunomodulatory research compound. As a structural analog of bacterial cell wall components, Romurtide retains the immune-activating properties of natural MDP while offering improved stability and reproducibility in experimental systems.

Mechanism of Immunomodulation

Romurtide acts as a cytokine inducer by stimulating innate immune pathways. It activates monocytes and macrophages, leading to the release of colony-stimulating factors (CSFs), interleukin-1 (IL-1), and interleukin-6 (IL-6). In vivo, it significantly increases circulating peripheral neutrophils and monocytes, enhancing innate immune responses.

This peptide-based immunomodulator has been investigated for its ability to enhance host defense, accelerate hematopoietic recovery, and augment antitumor immunity.

Research Relevance

• Immunology: Model compound for studying innate immune activation.

• Oncology: Enhances immunological defense mechanisms against tumor progression.

• Hematology: Stimulates neutrophil and monocyte recovery after cytotoxic treatments.

• Cytokine Biology: Provides a reproducible tool to study IL-1, IL-6, and CSF signaling.

Produced under GMP-grade standards, Romurtide ensures high purity, reproducibility, and biological integrity for reliable laboratory outcomes.

Disclaimer: For laboratory research use only. Not for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action

1. Innate Immune Activation

   • Mimics bacterial peptidoglycan fragments, triggering pattern-recognition receptors.

   • Activates macrophages and monocytes to release pro-inflammatory cytokines.

2. Cytokine Induction

   • Stimulates colony-stimulating factors (CSFs), essential for hematopoietic recovery.

   • Elevates IL-1 and IL-6, key regulators of inflammation and immune defense.

3. Hematopoietic Stimulation

   • Enhances production of neutrophils and monocytes in vivo.

   • Supports bone marrow recovery in cytotoxic stress conditions.

Research Applications

• Cancer Immunotherapy: Adjunct peptide for studying immune-based tumor suppression.

• Hematological Recovery: Useful in models of bone marrow suppression.

• Cytokine Pathways: Investigating IL-1/IL-6-mediated inflammatory cascades.

• Innate Immunity: Modeling host-pathogen interactions in immunology studies.

  

Side Effects (For Reference in Research Models)

• Cytokine Surge: High doses may cause excessive IL-1 and IL-6 release.

• Inflammatory Responses: Possible fever-like reactions in experimental animals.

• Immune Overactivation: Risk of exaggerated inflammatory responses at supra-physiological doses.

• Dose Dependency: Effects vary significantly based on experimental design and concentration.

These observations are from preclinical research contexts only and do not imply human clinical effects.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Romurtide

• Romurtide CAS 78113-36-7

• Muroctasin peptide

• Muramyl dipeptide derivative

• Cytokine inducer peptide

• Immunomodulator research compound

• GMP-grade Romurtide supplier

• CSF, IL-1, IL-6 inducer

• Hematopoietic stimulant peptide

• Laboratory-only peptide