Description

Product Description

Antioxidant Peptide A (CAS 159147-88-3) is a short synthetic peptide engineered with alternating aromatic and sulfur-containing amino acids, which confer strong antioxidant and radical scavenging properties. This design allows the peptide to interact effectively with reactive oxygen species (ROS) in cellular environments, particularly in cancer cell models.

Background and Research Significance

Reactive oxygen species (ROS) play a dual role in cancer biology: they can induce cell damage but also contribute to cell signaling and proliferation. Antioxidant Peptide A is designed to:

• Neutralize ROS and prevent oxidative damage in vitro.

• Investigate oxidative stress pathways in cancer and other disease models.

• Study the protective mechanisms of peptides in cell signaling and metabolism.

Its structure, rich in aromatic and sulfur-containing residues, enhances electron donation to radicals, providing effective radical scavenging activity. This makes it highly suitable for preclinical studies of oxidative stress, cancer biology, and therapeutic peptide development.

Chemical Properties and Structure

• Compound Class: Short synthetic peptide

• Target: Cellular ROS

• Mechanism: Radical scavenging via electron-rich side chains

• Activity: Antioxidant, cytoprotective in vitro

• Stability: Lyophilized peptide for long-term storage

• Applications: Oxidative stress research, cancer biology, preclinical peptide studies

Antioxidant Peptide A demonstrates high reproducibility, structural stability, and biological activity, making it a reliable tool for laboratory research.

Product Specifications

The specifications ensure high purity, reproducible antioxidant activity, and structural stability, supporting reliable experimental outcomes.

Mechanism of Action & Research Applications

Mechanism of Action

Antioxidant Peptide A exerts its biological activity by neutralizing reactive oxygen species (ROS) via the side chains of its aromatic and sulfur-containing amino acids:

1. Electron Donation: Aromatic residues donate electrons to free radicals, stabilizing them.

2. Sulfur-Mediated Radical Scavenging: Sulfur-containing residues (e.g., cysteine or methionine) provide additional antioxidant capacity through thiol-mediated reactions.

3. Cellular Protection: Reduces oxidative damage to lipids, proteins, and DNA in preclinical models.

This mechanism makes the peptide highly effective in in vitro oxidative stress studies, particularly in cancer cell lines where ROS levels are elevated.

Research Applications

1. Cancer Biology Research
Study oxidative stress and radical-induced damage in tumor cell lines.

2. Antioxidant Mechanism Studies
Investigate peptide-based radical scavenging pathways in cellular models.

3. Cytoprotective Research
Assess the protective effects of antioxidant peptides on cells exposed to ROS-inducing conditions.

4. Preclinical Peptide Development
Serve as a model for designing therapeutic antioxidant peptides.

5. Oxidative Stress Assays
Use in DCFH-DA, ROS fluorescence, or cell viability assays to quantify protective effects.

6. Combination Studies
Evaluate synergistic effects with chemotherapeutic or cytoprotective agents.

7. Mechanistic Insights
Analyze electron transfer pathways, thiol redox cycling, and radical stabilization.

8. Drug Screening Models
Apply in vitro to test small molecules or compounds for oxidative stress modulation.

9. Translational Research
Inform development of peptides as adjunct therapies for oxidative stress-related diseases.

10. Laboratory Protocol Optimization
Supports robust experimental design for ROS and oxidative damage research.

Side Effects (For Reference in Research Models)

Preclinical observations include:

• Dose-Dependent Activity: Higher concentrations may affect cell proliferation in sensitive lines.

• Cell Type Variability: Effects vary depending on cell line and ROS baseline levels.

• Stability Considerations: Avoid repeated freeze-thaw cycles to maintain antioxidant potency.

• Combination Effects: Co-treatment with other compounds may enhance or reduce activity.

These observations are strictly for laboratory research reference. Antioxidant Peptide A is not for human or veterinary use.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Antioxidant Peptide A CAS 159147-88-3

• Synthetic radical scavenging peptide

• Cancer cell ROS research peptide

• GMP-grade Antioxidant Peptide A

• In vitro oxidative stress peptide

• Cytoprotective research peptide

• Laboratory antioxidant peptide

• Preclinical peptide studies

• Aromatic/sulfur-containing peptide

• Research use only antioxidant agent