Description

Product Description

Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 (CAS 110590-61-9) is a bioactive nonapeptide derived from the laminin B1 chain, an essential component of the extracellular matrix (ECM). Laminins are large glycoproteins that form the structural foundation of basement membranes and play a pivotal role in cell adhesion, differentiation, migration, and signaling. This peptide sequence, corresponding to a specific biologically active domain within laminin, has been identified as a modulator of tumor cell adhesion and angiogenesis.

In tumor progression, the interaction between cancer cells and the ECM is critical for invasion and metastasis. Laminin-binding peptides derived from specific motifs can act as competitive inhibitors that block cancer cells from adhering to or degrading the basement membrane. The peptide Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 specifically inhibits the binding of tumor cells to laminin substrates and consequently reduces their invasive potential.

Experimental data suggest that this peptide suppresses endothelial cell migration and capillary-like tube formation, thereby inhibiting angiogenesis — a process indispensable for tumor growth and metastasis. Through this dual inhibitory action on both cancer cell adhesion and neovascularization, Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 has emerged as a valuable molecular tool for exploring tumor microenvironment dynamics and anti-metastatic therapies.

Its structural simplicity and high biological selectivity make it suitable for in vitro and in vivo studies aiming to delineate the complex network of ECM-tumor interactions. The presence of cysteine at the N-terminus may facilitate disulfide bond formation or conjugation for targeted delivery or labeling applications.

Applications include:

• Studying tumor invasion and metastasis mechanisms

• Evaluating angiogenesis inhibition in cancer models

• Investigating laminin–cell receptor interactions

• Designing novel anti-metastatic therapeutics

• Exploring ECM modulation and vascular biology

This peptide offers a precise and reproducible model to analyze how cancer cells respond to ECM-derived signals and provides a foundation for developing new anti-angiogenic and anti-metastatic strategies.

Product Specifications

Synonyms

• Laminin B1 chain fragment peptide

• CDPGYIGSR-NH2 peptide

• Laminin-derived anti-angiogenic peptide

• ECM-binding inhibitory peptide

Mechanism of Action

Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 functions as a competitive inhibitor of laminin receptor–mediated cell adhesion. Laminin, a major basement membrane glycoprotein, provides anchorage and signaling support for endothelial and epithelial cells. Cancer cells frequently exploit laminin–receptor interactions to adhere to the extracellular matrix, degrade its structure, and invade neighboring tissues.

This peptide, derived from the laminin B1 chain, binds to laminin receptor sites or mimics its binding motif, preventing tumor cells from attaching to native laminin substrates. As a result, it interferes with the initiation of invasion and metastatic spread.

Additionally, the peptide demonstrates anti-angiogenic properties by disrupting endothelial cell adhesion and migration, both essential steps in new capillary formation. In vitro and in vivo studies have shown that treatment with this peptide reduces neovascularization, microvessel density, and tumor vascularization, leading to restricted tumor growth.

At the molecular level, Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 modulates integrin-mediated signaling pathways, particularly those involving β1 and α6 integrins, thereby attenuating focal adhesion kinase (FAK) activation and downstream MAPK/ERK signaling. This leads to reduced motility and proliferation in endothelial and tumor cells.

Thus, this peptide represents a dual-function molecule with both anti-metastatic and anti-angiogenic activity — providing a potent research probe for tumor microenvironment modulation and ECM biology.

Side Effects / Safety Notes

Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 is designed for research use only and not intended for human or veterinary use. To date, no toxicological data in humans are available. Laboratory handling should be performed under appropriate biosafety conditions. Avoid inhalation, ingestion, or skin contact. Dispose of waste according to institutional safety protocols.

Disclaimer

All peptides and related reagents are supplied exclusively for laboratory research use. They are not intended for diagnostic, therapeutic, or clinical use. Product data are provided for informational purposes and may vary depending on research conditions.

Keywords

laminin-derived peptide, anti-angiogenic peptide, tumor invasion inhibitor, cancer metastasis peptide, ECM adhesion blocker, peptide supplier, custom peptide synthesis, research chemicals manufacturer, peptide for angiogenesis inhibition, peptide for tumor microenvironment studies

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