Description

Product Description

Caprooyl-tetrapeptide-3 triacetate is an innovative bioactive peptide engineered to promote the structural regeneration of the skin, reduce fine lines, and restore firmness. As a synthetic peptide derived from biomimetic amino acid sequences, it mimics the natural signaling molecules that regulate dermal repair and extracellular matrix (ECM) synthesis. This compound is a specialized derivative of tetrapeptide-3, further enhanced by caproic acid modification and triacetate stabilization, providing superior lipophilicity and dermal penetration.

In the field of cosmetic peptide research, Caprooyl-tetrapeptide-3 triacetate has gained significant attention due to its ability to enhance dermal–epidermal cohesion. It acts by stimulating the production of collagen VII and laminin-5, two essential proteins involved in anchoring the dermal and epidermal layers. This dual activation mechanism strengthens the skin’s basement membrane, resulting in visible anti-wrinkle benefits and improved tissue elasticity.

Researchers have demonstrated that Caprooyl-tetrapeptide-3 triacetate can counteract corticoid-induced skin aging, a common model used to simulate dermal thinning and ECM degradation. In such models, this peptide restores the synthesis of key structural components, including fibronectin and hyaluronic acid, contributing to improved skin density and mechanical resilience.

Beyond its anti-aging potential, this compound also provides antioxidative protection, helping mitigate damage caused by free radicals, UV radiation, and environmental stressors. The lipophilic caprooyl modification improves dermal bioavailability, allowing deeper penetration into the skin’s matrix where regeneration processes occur.

Due to these synergistic effects, Caprooyl-tetrapeptide-3 triacetate has become an important subject in cosmetic and dermatological peptide research, particularly for the formulation of serums, creams, and repair emulsions designed for skin rejuvenation.

Its scientific relevance extends beyond aesthetic enhancement — it also serves as a model peptide for studying peptide-based signaling in tissue repair, ECM communication, and dermal regeneration biology.

In addition, its stability under physiological pH and thermal conditions makes it a robust compound for formulation studies, providing consistent activity across various cosmetic delivery systems such as liposomes, gels, or nanoemulsions.

Overall, Caprooyl-tetrapeptide-3 triacetate represents a scientifically advanced peptide model that combines biomimetic precision with cosmetic relevance. It supports ongoing innovation in anti-aging and dermal restoration research, aligning perfectly with next-generation cosmetic biotechnology focused on skin structure and resilience.

Product Specifications

Mechanism of Action

Caprooyl-tetrapeptide-3 triacetate exerts its biological effects through a multifaceted mechanism targeting both dermal and epidermal layers. It operates as a biomimetic peptide that replicates the activity of natural growth factors responsible for dermal matrix synthesis and intercellular communication.

1. Stimulation of Collagen VII and Laminin-5 Synthesis
   The peptide upregulates the expression of key structural proteins in fibroblasts, particularly collagen VII and laminin-5. These molecules form anchoring fibrils that connect the dermal and epidermal layers, ensuring cohesive strength and smooth skin surface.

2. Reinforcement of the Dermal-Epidermal Junction (DEJ)
   By promoting ECM remodeling, Caprooyl-tetrapeptide-3 triacetate helps rebuild the DEJ, a region that deteriorates with age and oxidative stress. This action enhances mechanical stability and reduces wrinkle depth by strengthening skin attachment.

3. Stimulation of ECM Protein Production
   It enhances the synthesis of fibronectin, elastin, and glycosaminoglycans, which collectively restore dermal volume and elasticity. The result is a visible improvement in firmness and suppleness, critical indicators of youthful skin.

4. Reduction of Corticoid-Induced Skin Damage
   In skin aging models where corticosteroids induce ECM breakdown, this peptide counteracts degradation by promoting biosynthesis of collagen VII and laminin-5 while inhibiting inflammatory mediators that accelerate dermal thinning.

5. Antioxidant and Anti-Inflammatory Effects
   Caprooyl-tetrapeptide-3 triacetate helps protect fibroblasts and keratinocytes from oxidative stress by reducing ROS accumulation. It indirectly inhibits NF-κB-mediated inflammation, minimizing dermal matrix degradation.

6. Enhanced Dermal Penetration
   The caprooyl modification improves skin permeation, facilitating transport across the lipid barrier, while triacetate stabilization preserves peptide structure and activity. This modification allows sustained dermal exposure for more efficient results in topical research applications.

7. Regulation of Cellular Communication
   The peptide promotes cross-talk between fibroblasts and keratinocytes, fostering a synchronized environment for tissue repair. This intercellular communication is essential for balanced ECM turnover and regeneration.

   

Side Effects

Caprooyl-tetrapeptide-3 triacetate has been shown to exhibit excellent biocompatibility in laboratory testing. No cytotoxic or irritant effects were observed at typical research concentrations.

• Safety Profile:
  It demonstrates non-sensitizing and non-irritating characteristics when applied to reconstructed human epidermis models.

• Allergenicity:
  No allergic or immunogenic reactions have been reported in in vitro assays.

• Usage Considerations:
  As with all research compounds, appropriate handling procedures should be followed. Avoid ingestion or direct contact with mucosal tissues. The compound should be used in controlled laboratory environments only.

Overall, its safety and tolerability make Caprooyl-tetrapeptide-3 triacetate an ideal candidate for further cosmetic peptide exploration and formulation testing.

Keywords

Caprooyl-tetrapeptide-3 triacetate, anti-aging peptide, collagen stimulation, ECM repair, wrinkle reduction, skin firming, cosmetic peptide supplier, factory peptide wholesale, China peptide manufacturer, OEM peptide production, high-purity peptide, bulk peptide powder.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.