Description
ABT-510 Acetate is a synthetic nine-amino-acid peptide derived from the type 1 repeat of thrombospondin-1 (TSP-1). It mimics TSP-1’s anti-angiogenic function by binding to CD36 receptors, inducing apoptosis in microvessel endothelial cells, and inhibiting tumor neovascularization. Preclinical studies demonstrate its efficacy in reducing ovarian tumor growth, reducing microvessel density, and enhancing chemotherapy delivery via vascular normalization. Manufactured under GMP conditions with ? 99.61% purity.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | ABT-510 Acetate |
| Synonyms | ABT-510; TSP-1 mimetic peptide |
| CAS No. | 442526-87-6 |
| Purity | ? 99.61% (GMP-grade) |
| Molecular Formula | C??H??N??O?? |
| Molecular Weight | ~1054.28 Da |
| Appearance | White to off-white solid |
| Solubility | Soluble in water (up to 100 mg/mL with sonication); compatible with DMSO |
| Storage Conditions | Store at –20 °C, dry and light-protected |
| Manufacturing Standard | GMP-compliant |
| Applications | Anti-angiogenesis research, tumor and inflammation models |
| Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
ABT-510 Acetate mimics TSP-1 by binding to CD36 receptors on endothelial cells, triggering caspase-8-dependent apoptosis and inhibiting vascular tube formation. It has demonstrated potent anti-angiogenic effects, tumor growth inhibition, and reduced inflammation in preclinical models including ovarian cancer and inflammatory bowel disease.
Disclaimer
This product is intended strictly for laboratory research use only. It is not approved for human or veterinary use. Handle in accordance with institutional safety protocols.


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