Description

Product Description

Ac-KLKKTETQ-NH2 is a short synthetic peptide derived from amino acid sequences relevant to dermal regeneration. Its structure enables interaction with key signaling pathways in fibroblasts and keratinocytes, facilitating enhanced extracellular matrix synthesis, improved skin hydration, and anti-aging effects.

In vitro research indicates that Ac-KLKKTETQ-NH2 promotes fibroblast proliferation and upregulates genes responsible for collagen types I and III, elastin, and fibronectin production. By improving ECM density, the peptide contributes to skin firmness, elasticity, and wrinkle reduction.

The peptide also modulates inflammatory signaling pathways, reducing pro-inflammatory cytokines such as IL-6 and TNF-α in cultured dermal cells. This anti-inflammatory property supports the maintenance of a healthy dermal microenvironment, promoting cellular repair and resilience against oxidative stress.

Due to its small size and amphiphilic properties, Ac-KLKKTETQ-NH2 exhibits efficient penetration into the epidermis in experimental topical formulations, making it suitable for laboratory studies on serums, creams, or emulsions.

Synergistic research demonstrates enhanced outcomes when combined with other cosmetic peptides, such as palmitoyl tripeptides or acetyl hexapeptides, as well as antioxidants like vitamin C or niacinamide. Such combinations are shown to improve dermal matrix regeneration, wrinkle reduction, and skin hydration in controlled experiments.

Overall, Ac-KLKKTETQ-NH2 serves as a versatile research peptide for investigating anti-aging mechanisms, ECM restoration, fibroblast activation, and skin barrier enhancement in cosmetic science and dermatological research.

Product Specifications

Mechanism of Action

Ac-KLKKTETQ-NH2 acts through multiple complementary mechanisms to support skin regeneration and anti-aging research.

1. Fibroblast Activation

The peptide stimulates dermal fibroblasts, increasing proliferation and metabolic activity. Activated fibroblasts synthesize structural proteins essential for dermal integrity.

2. ECM Gene Upregulation

Ac-KLKKTETQ-NH2 upregulates genes encoding collagen I, collagen III, elastin, and fibronectin. This leads to enhanced extracellular matrix density, improved skin elasticity, and wrinkle reduction.

3. Collagen and Hyaluronic Acid Synthesis

The peptide promotes collagen and hyaluronic acid production, increasing skin hydration and resilience. ECM reinforcement contributes to smoother, firmer skin.

4. Anti-Inflammatory Modulation

Ac-KLKKTETQ-NH2 reduces pro-inflammatory markers (IL-6, TNF-α), minimizing dermal stress and supporting a regenerative microenvironment.

5. Anti-Aging and Wrinkle Reduction

By inhibiting matrix metalloproteinases (MMP-1, MMP-9) and enhancing fibroblast function, the peptide reduces ECM degradation, contributing to visible wrinkle reduction in laboratory studies.

6. Synergistic Effects

Co-application with other peptides or antioxidants enhances ECM remodeling, dermal hydration, and anti-aging activity, offering valuable insights in cosmetic formulation research.

7. Molecular Pathway Regulation

Ac-KLKKTETQ-NH2 influences TGF-β/SMAD and MAPK/ERK signaling pathways, promoting collagen transcription, cell proliferation, and anti-inflammatory responses.

Side Effects

• Cytotoxicity: Minimal in vitro; safe within recommended research concentrations.

• Irritation: No significant irritation observed in reconstructed human epidermal models.

• Phototoxicity: Not phototoxic under standard laboratory light conditions.

• Stability Considerations: Sensitive to UV light, high temperature, and extreme pH. Store at 2–8 °C, protected from light and moisture.

• Experimental Guidance: Concentration-dependent cytotoxicity tests are recommended prior to formulation studies.

Ac-KLKKTETQ-NH2 is intended strictly for research purposes and is not suitable for ingestion, injection, or clinical use.

Keywords

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Shipping Guarantee

All Ac-KLKKTETQ-NH2 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Ac-KLKKTETQ-NH2 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Ac-KLKKTETQ-NH2 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Ac-KLKKTETQ-NH2 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.