Description

Product Description

Acetyl dipeptide-1 cetyl ester (Calmosensine) is a synthetic bioactive peptide widely utilized in cosmetic research for its skin-soothing and anti-aging effects. As a dipeptide derivative with a cetyl ester modification, it demonstrates excellent skin penetration and stability, making it a preferred ingredient in high-performance cosmetic formulations. Its molecular structure allows for deep interaction with epidermal and dermal cells, facilitating modulation of skin homeostasis and reduction of inflammatory responses triggered by environmental stressors such as UV radiation and pollution.

The primary function of Acetyl dipeptide-1 cetyl ester is to calm irritated and stressed skin by regulating neuropeptide-mediated signaling pathways. It acts on epidermal neurons and keratinocytes to decrease the release of pro-inflammatory neuropeptides such as substance P, thereby reducing redness, irritation, and discomfort. This makes it particularly valuable in formulations aimed at sensitive or reactive skin types.

In addition to its soothing effect, Acetyl dipeptide-1 cetyl ester supports structural integrity of the dermis. By stimulating fibroblast activity and extracellular matrix (ECM) protein synthesis—including collagen, elastin, and fibronectin—it contributes to enhanced skin elasticity, firmness, and resilience. This action helps to reduce the appearance of fine lines and wrinkles while promoting overall skin smoothness.

Research indicates that this peptide also provides antioxidant protection, mitigating oxidative stress caused by reactive oxygen species (ROS) and environmental damage. Its dual mechanism of calming inflammation and promoting dermal structure makes it a versatile ingredient in anti-aging skincare research and cosmetic product development.

Commercially, Acetyl dipeptide-1 cetyl ester is incorporated into serums, creams, masks, and other topical formulations targeting sensitive, aging, or stressed skin. It demonstrates excellent compatibility with other cosmetic actives, such as hyaluronic acid, niacinamide, or other peptides, enabling synergistic effects that enhance overall skin rejuvenation.

Product Specifications

Mechanism of Action

Acetyl dipeptide-1 cetyl ester functions primarily as a skin-calming and anti-aging peptide. Its key mechanisms include modulation of neuropeptide release, stimulation of fibroblast activity, and antioxidant protection.

1. Neuropeptide Modulation: The peptide reduces the release of stress-induced neuropeptides in the epidermis, such as substance P, which mediates inflammatory and vasodilatory responses. By dampening this signaling, the peptide alleviates redness, irritation, and discomfort in sensitive or stressed skin.

2. Fibroblast Activation: Acetyl dipeptide-1 cetyl ester enhances fibroblast proliferation and increases ECM protein synthesis, particularly collagen types I and III, elastin, and fibronectin. This structural reinforcement improves skin elasticity, reduces wrinkle depth, and maintains skin firmness.

3. Antioxidant Protection: The peptide scavenges reactive oxygen species (ROS) and mitigates oxidative stress, protecting dermal and epidermal cells from environmental damage, UV exposure, and aging-related cellular dysfunction.

4. Synergistic Effects: When combined with other cosmetic actives, including hyaluronic acid, other bioactive peptides, and antioxidants, Acetyl dipeptide-1 cetyl ester amplifies anti-aging effects, providing improved hydration, barrier function, and skin smoothness.

5. Skin Barrier Support: By improving ECM density and integrity, it enhances skin barrier function, reduces transepidermal water loss, and supports long-term skin health.

These mechanisms collectively contribute to visible anti-aging benefits, including reduced fine lines, improved elasticity, enhanced hydration, and overall skin rejuvenation.

Side Effects

Acetyl dipeptide-1 cetyl ester is generally well-tolerated in cosmetic and laboratory research. No significant cytotoxicity has been reported at concentrations commonly used in cosmetic formulations. Minor local reactions such as transient erythema or mild irritation may occur in sensitive models. Recommended precautions include:

• Store under recommended conditions to maintain stability.

• Avoid repeated freeze-thaw cycles.

• Handle in compliance with standard laboratory safety protocols.

• Use appropriate concentrations in cosmetic formulation studies.

Overall, Acetyl dipeptide-1 cetyl ester exhibits an excellent safety profile for cosmetic research and topical applications.

Keywords

Acetyl dipeptide-1 cetyl ester, Calmosensine, Anti-Aging Peptide, Skin Calming Peptide, Cosmetic Peptide, Fibroblast Activator, Sensitive Skin Research, Cosmetic Raw Material, High-Purity Peptide, Freeze-Dried Powder

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Acetyl dipeptide-1 cetyl ester product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Acetyl dipeptide-1 cetyl ester provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Acetyl dipeptide-1 cetyl ester products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.