Description

Product Description

Acetyl heptapeptide-4 is a synthetic bioactive peptide developed for advanced cosmetic and dermatological research focusing on sensitive skin, allergy-prone skin, and barrier dysfunction. This seven-amino-acid sequence is acetylated to enhance its molecular stability and improve transdermal penetration. It has demonstrated strong anti-allergic and anti-inflammatory activity in in vitro studies, making it a valuable ingredient in modern cosmetic peptide research.

The peptide primarily functions as a neuromodulatory and immunomodulatory signaling molecule, influencing the communication between epidermal keratinocytes, dermal fibroblasts, and immune cells such as mast cells and Langerhans cells. By regulating these interactions, Acetyl heptapeptide-4 helps minimize the excessive inflammatory reactions that often cause skin redness, irritation, and hypersensitivity.

From a biochemical perspective, Acetyl heptapeptide-4 works by downregulating key mediators of neurogenic inflammation, including Substance P (SP), Calcitonin Gene-Related Peptide (CGRP), and Prostaglandin E2 (PGE2). It further inhibits the overproduction of pro-inflammatory cytokines such as IL-1α, IL-6, and TNF-α while enhancing the synthesis of epidermal lipids and tight junction proteins critical for maintaining barrier integrity.

Research has shown that topical formulations containing Acetyl heptapeptide-4 can help restore normal barrier function and reduce the stinging or itching sensations associated with environmental stress or product overuse. These properties make it particularly relevant for sensitive-skin models, post-procedure recovery formulations, and barrier-repair cosmetic studies.

Acetyl heptapeptide-4’s acetyl modification enhances its lipophilicity, allowing better skin penetration and prolonged bioavailability compared to non-acetylated analogs. The heptapeptide sequence itself is engineered to mimic natural skin defense peptides, thus supporting the skin’s innate immune balance. Through this dual mechanism — strengthening the barrier and modulating inflammatory response — Acetyl heptapeptide-4 stands out as an innovative tool in cosmetic peptide research.

Researchers have also explored its role in reducing allergic-type responses triggered by irritants and allergens. In controlled cell culture experiments, Acetyl heptapeptide-4 was shown to inhibit mast cell degranulation and histamine release, indicating its capacity to minimize redness and discomfort associated with allergic reactions. Moreover, its low cytotoxicity profile makes it a safe and reliable candidate for topical peptide formulation studies.

With the rising prevalence of sensitive skin conditions due to pollution, lifestyle stress, and cosmetic overexposure, Acetyl heptapeptide-4 provides a scientifically validated solution for soothing irritation and restoring barrier function. As part of ongoing cosmetic peptide innovation, it continues to serve as an essential molecule in research dedicated to skin homeostasis, inflammation control, and dermal resilience.

Product Specifications

Mechanism of Action

Acetyl heptapeptide-4 exerts its biological effects through a multifactorial mechanism involving both immune and neural pathways. Its activity in modulating inflammatory responses and promoting skin homeostasis has been well characterized in cosmetic and dermatological research.

1. Inhibition of Neurogenic Inflammation

The peptide modulates the release of neuropeptides such as Substance P and CGRP from sensory nerve endings. These neuropeptides are key mediators of neurogenic inflammation, which is responsible for sensations of stinging, redness, and discomfort in sensitive skin. By suppressing these mediators, Acetyl heptapeptide-4 helps restore normal skin sensitivity thresholds and reduces inflammation-related erythema.

2. Suppression of Pro-Inflammatory Cytokines

Through cellular signaling pathways involving NF-κB and AP-1, Acetyl heptapeptide-4 inhibits the production of inflammatory cytokines like IL-1α, IL-6, and TNF-α. This action prevents the amplification of inflammatory cascades that contribute to skin irritation and allergic responses. The result is a visible reduction in redness and swelling, as demonstrated in laboratory keratinocyte and fibroblast co-culture models.

3. Mast Cell Stabilization

Acetyl heptapeptide-4 helps prevent mast cell degranulation, a process that releases histamine and other inflammatory mediators responsible for itching and allergic reactions. Stabilizing mast cells is critical in maintaining skin comfort and preventing overreaction to environmental stimuli, fragrances, or harsh surfactants.

4. Enhancement of Skin Barrier Function

The peptide increases the expression of key structural proteins such as filaggrin, involucrin, and occludin, which are integral components of the epidermal barrier. It also promotes the synthesis of ceramides and fatty acids, essential for maintaining hydration and reducing trans-epidermal water loss (TEWL). This leads to more resilient skin capable of defending itself against irritants and allergens.

5. Immune Balance and Homeostasis

By modulating the crosstalk between keratinocytes and immune cells, Acetyl heptapeptide-4 promotes a balanced immune response. It encourages the release of anti-inflammatory cytokines like IL-10, reducing hypersensitivity reactions while preserving the skin’s natural defense capabilities.

6. Cellular Antioxidant Defense

The peptide indirectly enhances the skin’s antioxidant response by upregulating genes associated with detoxification and reactive oxygen species (ROS) neutralization. These effects contribute to the prevention of oxidative stress-induced inflammation, further protecting sensitive skin.

7. Synergistic Use with Barrier-Repair Actives

In research formulations, Acetyl heptapeptide-4 has been shown to complement ingredients such as panthenol, niacinamide, and ceramides. This synergy promotes accelerated recovery in barrier-compromised skin and enhances comfort in individuals prone to sensitivity or redness.

Side Effects

Acetyl heptapeptide-4 has demonstrated excellent biocompatibility and safety in vitro and in reconstructed human epidermal models. No cytotoxicity, irritation, or sensitization was observed within typical experimental concentration ranges.

The peptide should, however, be handled under controlled laboratory conditions to maintain stability and prevent contamination. It is recommended to perform patch compatibility and concentration-dependent cytotoxicity studies when developing new formulations.

Overexposure to light or elevated temperatures may reduce its stability; therefore, proper storage (2–8 °C) is crucial. The peptide is strictly intended for laboratory research use and not for direct application to human subjects or therapeutic use.

Keywords

Acetyl heptapeptide-4, anti-allergic peptide, skin barrier peptide, soothing peptide, cosmetic peptide, sensitive skin research, peptide supplier China, OEM peptide production, high-purity cosmetic peptides, bulk peptide manufacturer

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.