Description

Product Description

Acetyl hexapeptide-1 acetate is a synthetic bioactive peptide consisting of six amino acids, specifically engineered to target mechanisms associated with skin aging and wrinkle formation. In laboratory research, it functions as a neuromodulatory peptide that interferes with the release of neurotransmitters responsible for repetitive facial muscle contractions, which contribute to the formation of fine lines and expression wrinkles.

The peptide exhibits significant anti-wrinkle potential by modulating the communication between nerve endings and muscle fibers in controlled experimental models. It acts through pathways similar to naturally occurring peptides in the skin that regulate muscle contraction and relaxation cycles. Its efficacy in reducing visible wrinkles has been demonstrated in in vitro dermal fibroblast models and reconstructed human skin tissue models.

Acetyl hexapeptide-1 acetate is highly soluble in aqueous buffers, allowing incorporation into cosmetic research formulations such as serums, creams, and peptide blends. Researchers often investigate its synergistic potential with other cosmetic peptides and antioxidants, including Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and L-Glutathione, to explore enhanced anti-aging effects.

Mechanistically, Acetyl hexapeptide-1 acetate inhibits SNARE complex formation, which reduces acetylcholine release at the neuromuscular junction. This controlled neurotransmitter modulation leads to decreased repetitive contraction of facial muscles, ultimately mitigating the appearance of expression wrinkles. Furthermore, it supports dermal extracellular matrix maintenance by indirectly promoting collagen and elastin synthesis, contributing to improved skin elasticity and resilience.

Laboratory studies indicate that Acetyl hexapeptide-1 acetate not only reduces wrinkle depth but also modulates cellular pathways associated with oxidative stress and inflammatory responses, which are key contributors to skin aging. Its peptide structure allows for stable incorporation into various delivery systems, preserving bioactivity throughout experimental procedures.

This peptide has become a standard reference molecule in cosmetic peptide research for investigating wrinkle reduction, skin relaxation, and the molecular mechanisms underlying facial aging. Its combination of neuromodulatory action and dermal support makes it a versatile tool for preclinical studies on peptide-based anti-aging interventions.

Product Specifications

Mechanism of Action

Acetyl hexapeptide-1 acetate works primarily by modulating neuromuscular signaling at the skin-muscle interface. In in vitro models, it interferes with SNARE complex formation, which is essential for the exocytosis of acetylcholine from presynaptic nerve terminals. Reduced acetylcholine release limits repetitive micro-contractions of facial muscles, a key factor in expression wrinkle formation.

By controlling these micro-contractions, Acetyl hexapeptide-1 acetate decreases mechanical stress on the dermis, preserving collagen and elastin networks. Laboratory evidence also suggests it may stimulate fibroblast activity, leading to improved extracellular matrix synthesis, dermal density, and skin elasticity.

Additionally, this peptide contributes to cellular protection against oxidative stress, which can accelerate wrinkle formation. Its presence in peptide formulations has been shown to synergize with antioxidant compounds, mitigating ROS-mediated damage to dermal fibroblasts and supporting healthier skin architecture.

Tetrapeptide and hexapeptide combinations are often studied with Acetyl hexapeptide-1 acetate to examine enhanced anti-aging outcomes. Its stability, solubility, and efficacy make it a reliable molecule for cosmetic peptide research, particularly for studies on wrinkle prevention, expression line reduction, and formulation optimization.

Side Effects

Laboratory studies indicate excellent tolerability of Acetyl hexapeptide-1 acetate at experimental concentrations. Key safety considerations include:

• Concentration-dependent effects: Optimal dosing is required in in vitro models to avoid potential cytotoxicity.

• Formulation interactions: While compatible with most cosmetic actives, buffer pH and formulation matrix may influence peptide stability.

• Handling precautions: Designed strictly for laboratory research. Wear protective gloves, lab coat, and safety goggles. Avoid ingestion, inhalation, or direct eye contact.

• Storage recommendations: Store at -20°C, shielded from light and moisture to maintain stability and bioactivity.

No systemic or severe cytotoxic effects have been reported in preclinical experiments, making this peptide safe for laboratory cosmetic studies.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.