Description
Product Description
Acetyl hexapeptide-37 is a chemically synthesized bioactive peptide consisting of six amino acids, modified with an acetyl group to improve stability and skin penetration. With a CAS number of 1447824-16-9, it has been widely investigated in cosmetic research for its anti-aging properties and ability to promote skin rejuvenation.
This peptide acts by stimulating dermal fibroblasts, enhancing the synthesis of extracellular matrix proteins such as collagen, elastin, and fibronectin. By increasing collagen deposition, Acetyl hexapeptide-37 strengthens skin structure, improving elasticity and firmness, which are critical for reducing wrinkles and visible aging signs.
Acetyl hexapeptide-37 also protects skin cells from oxidative stress by reducing reactive oxygen species (ROS) levels, supporting cellular repair and improving tissue resilience. It helps preserve the extracellular matrix by inhibiting matrix metalloproteinases (MMPs), enzymes that degrade collagen, thereby maintaining dermal integrity over time.
When combined with other cosmetic peptides, Acetyl hexapeptide-37 can provide synergistic effects, enhancing wrinkle reduction, skin hydration, and overall anti-aging activity. Its small size and acetyl modification allow efficient skin penetration, making it a valuable tool for topical cosmetic peptide research.
Researchers utilize Acetyl hexapeptide-37 to study fibroblast signaling pathways, extracellular matrix remodeling, and the molecular mechanisms underlying skin aging, providing a basis for developing high-performance cosmetic formulations.

Product Specifications
| Item | Specification |
|---|---|
| Product Name | Acetyl hexapeptide-37 |
| Synonyms | Ac-Hexapeptide-37, Anti-aging hexapeptide |
| CAS Number | 1447824-16-9 |
| Molecular Formula | CₓHₓNₓOₓ (depends on peptide sequence) |
| Molecular Weight | Approx. 800–1000 Da |
| Purity | ≥99% |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and phosphate-buffered solutions |
| Storage | Store at −20°C, protect from light and moisture |
| Stability | Stable for 24 months under recommended conditions |
| Applications | Anti-aging cosmetic research, collagen stimulation studies, skin elasticity enhancement |
| Intended Use | For laboratory research use only |
| Supplier Type | Cosmetic peptide manufacturer, OEM peptide supplier |
Mechanism of Action
Acetyl hexapeptide-37 operates via multiple mechanisms to support skin rejuvenation:
Collagen Stimulation:
Enhances type I and III collagen production, improving dermal density and skin firmness.Elastin and Fibronectin Synthesis:
Promotes elastin and fibronectin generation, increasing elasticity and structural support.Matrix Preservation:
Reduces the activity of matrix metalloproteinases (MMPs), slowing collagen degradation.Antioxidant Protection:
Mitigates ROS damage, protecting fibroblasts and supporting tissue resilience.Cellular Repair:
Stimulates fibroblast proliferation and extracellular matrix organization, promoting skin repair.
These combined effects make Acetyl hexapeptide-37 a robust candidate for cosmetic research focused on anti-aging, wrinkle reduction, and skin firming.

Side Effects
Laboratory studies show Acetyl hexapeptide-37 has excellent biocompatibility at experimental concentrations, with no cytotoxic effects reported. It is intended for research purposes only and should not be administered to humans or animals. Standard laboratory safety procedures, including PPE and sterile handling, are required.
Keywords
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Shipping Guarantee
All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance
We Acetyl hexapeptide-37 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.
Payment Support
We Acetyl hexapeptide-37 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.
Disclaimer
All Acetyl hexapeptide-37 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.







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