Description

Product Description

Acetyl hexapeptide-49 is a synthetic hexapeptide designed to improve skin resilience and comfort by modulating neuro-sensory responses and barrier homeostasis. Known as an effective anti-irritation and skin-calming agent, it acts at the molecular level to reduce hypersensitivity reactions, making it valuable in dermatological and cosmetic peptide research aimed at sensitive or reactive skin.

This peptide was originally developed to alleviate stimulation in mammalian skin cells while maintaining cell vitality and structural cohesion. Studies indicate that Acetyl hexapeptide-49 influences the expression of genes related to inflammatory modulation and sensory nerve activity. By decreasing the production of neuropeptides such as substance P and CGRP (Calcitonin Gene-Related Peptide), it helps mitigate redness, itching, and discomfort associated with external irritants.

From a biochemical perspective, the acetylation of the peptide sequence enhances its lipophilicity, allowing better dermal penetration and interaction with sensory receptors in the skin. This modification increases stability during formulation and improves its performance in topical applications. Moreover, Acetyl hexapeptide-49 promotes keratinocyte differentiation and lipid synthesis, two key processes involved in maintaining a healthy epidermal barrier.

Laboratory investigations have shown that this peptide can protect skin cells exposed to chemical irritants, UV radiation, or mechanical stress, effectively reducing inflammatory signaling and oxidative imbalance. By enhancing cell viability and supporting the synthesis of ceramides and structural proteins, Acetyl hexapeptide-49 contributes to a more balanced and tolerant epidermis.

In cosmetic research, Acetyl hexapeptide-49 is often studied as an ingredient for soothing and repairing formulations targeting sensitive, reactive, or redness-prone skin. It demonstrates compatibility with a broad range of active peptides, humectants, and lipid-restoring compounds, allowing synergistic effects in complex formulations. Furthermore, its ability to regulate sensory responses makes it particularly useful in research related to neurocosmetic peptide development.

Molecular and Functional Insights

Acetyl hexapeptide-49 operates through the modulation of the skin’s neuro-immuno-cutaneous system (NICS), which governs how nerve endings and immune cells respond to external stress. By rebalancing this interaction, the peptide can prevent exaggerated sensory reactions, often the root cause of irritation and chronic sensitivity. This biological approach differentiates it from traditional anti-inflammatory compounds, providing a more targeted pathway for soothing skin research.

In vitro and ex vivo tests have revealed improvements in transepidermal water loss (TEWL), skin hydration, and recovery time after chemical stress exposure. Researchers have also noted enhanced tolerance to surfactants and other irritant compounds when pre-treated with Acetyl hexapeptide-49, indicating its protective and conditioning benefits.

Overall, this peptide represents a new generation of neuro-soothing cosmetic actives, bridging molecular dermatology and skin barrier science. Its multi-targeted mechanism aligns with the growing demand for gentle yet effective bioactives that restore balance to sensitive and reactive skin conditions.

Product Specifications

Mechanism of Action

Acetyl hexapeptide-49 exerts its biological activity primarily through neurosensory regulation and inflammation modulation, making it distinct from standard anti-inflammatory compounds.

1. Sensory Nerve Signal Regulation

It interacts with neuronal receptors to reduce the release of neuropeptides involved in irritation, including substance P and CGRP. This action helps attenuate the perception of burning, stinging, and itching sensations while supporting a more balanced nerve–skin communication network.

2. Cytokine and Chemokine Downregulation

The peptide reduces pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, preventing the cascade of irritation and redness typically associated with contact sensitivity. This process leads to a more resilient, less reactive skin profile.

3. Barrier Reinforcement and Lipid Metabolism

Acetyl hexapeptide-49 enhances the synthesis of key lipids and structural proteins, including ceramides, filaggrin, and involucrin. These molecules are crucial for maintaining an intact stratum corneum, reducing transepidermal water loss (TEWL), and improving hydration levels.

4. Neuro-Immune Balance Restoration

This peptide modulates cross-talk between nerve endings and immune cells in the epidermis, promoting equilibrium within the neuro-immuno-cutaneous system. It ensures the immune response remains protective without triggering excessive inflammation.

5. Cellular Viability and Stress Resistance

In vitro experiments demonstrate improved keratinocyte survival and mitochondrial stability when cells are pre-treated with Acetyl hexapeptide-49. The peptide mitigates oxidative stress and maintains cellular vitality, ensuring optimal skin function even under environmental aggressors.

6. Compatibility and Synergistic Action

Acetyl hexapeptide-49 shows high compatibility with calming agents like panthenol, bisabolol, and palmitoyl tripeptides, amplifying the overall soothing and reparative potential of cosmetic research formulations. This versatility makes it a valuable component in multi-functional skincare research.

Side Effects

Acetyl hexapeptide-49 demonstrates a highly favorable safety profile in laboratory conditions. Cytotoxicity tests confirm that the peptide maintains cell viability even at high research concentrations. No signs of irritation, sensitization, or phototoxicity have been observed in reconstructed human epidermis models.

However, as with all research peptides, optimal results depend on concentration and formulation stability. Overexposure to high temperature, oxidation, or UV light should be avoided to preserve bioactivity. Researchers are advised to perform standard in vitro safety assessments to verify compatibility before incorporating it into advanced cosmetic studies.

This peptide is considered safe for experimental use but not for direct human or veterinary application.

Keywords

Acetyl hexapeptide-49, anti-allergen peptide, skin-soothing peptide, sensitive skin research, anti-inflammatory cosmetic peptide, cosmetic peptide manufacturer, high-purity peptide supplier, OEM cosmetic peptide, China peptide manufacturer

Shipping Guarantee

All Acetyl Hexapeptide-49 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Acetyl Hexapeptide-49 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Acetyl Hexapeptide-49 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Acetyl Hexapeptide-49 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.