Description

Product Description

Acetyl Octapeptide-1 (CAS 868844-74-0) is a next-generation bioactive peptide designed for advanced cosmetic research targeting wrinkle reduction and anti-aging effects. Also known as SNAP-8, this octapeptide functions as an innovative neurotransmitter-inhibiting molecule that mimics the N-terminal end of SNAP-25, a substrate of botulinum toxin. By competitively inhibiting the SNAP-25 complex formation, Acetyl Octapeptide-1 reduces the release of catecholamines and acetylcholine, resulting in a visible relaxation of facial muscles and diminished expression lines.

In cosmetic peptide research, Acetyl Octapeptide-1 is often described as a “non-invasive alternative to Botox” due to its ability to attenuate muscle contractions responsible for wrinkles, while maintaining the natural mobility of facial expressions. This mechanism has made it one of the most widely investigated peptides for topical anti-aging and wrinkle-prevention formulations.

When incorporated into formulations, Acetyl Octapeptide-1 supports multiple biological pathways beyond neuromodulation. It enhances fibroblast activity, upregulates collagen type I synthesis, and promotes extracellular matrix (ECM) regeneration. These combined effects lead to smoother, firmer, and more elastic skin profiles in in-vitro and ex-vivo models.

Its efficacy has been demonstrated in numerous skin model studies, showing reductions in wrinkle depth, increased dermal density, and improved hydration balance. These properties make Acetyl Octapeptide-1 a research cornerstone for developing next-generation anti-aging creams, serums, and cosmeceuticals.

In peptide-based cosmetic formulation research, Acetyl Octapeptide-1 is valued for:

• Wrinkle attenuation: By reducing neurotransmitter release, it minimizes the mechanical stress on skin tissues.

• Enhanced elasticity: Promotes ECM integrity by supporting collagen and elastin synthesis.

• Moisture retention: Improves stratum corneum hydration and barrier recovery.

• Cellular repair: Encourages dermal fibroblast proliferation and repair responses.

Furthermore, its non-cytotoxic and stable molecular profile allows formulation compatibility with various cosmetic delivery systems, including liposomes, nanoemulsions, and hydrogel matrices. This makes it particularly suitable for research on peptide stability, bioavailability, and skin-penetration optimization.

Product Specifications

Mechanism of Action

Acetyl Octapeptide-1 works by interfering with synaptic vesicle exocytosis at the neuromuscular junction. It binds competitively to SNAP-25, a component of the SNARE complex responsible for vesicle fusion. By preventing the formation of the SNARE complex, Acetyl Octapeptide-1 effectively reduces the release of neurotransmitters such as acetylcholine, which are responsible for repetitive muscle contractions that lead to expression lines and wrinkles.

This mechanism mirrors that of botulinum toxin but provides a non-invasive, reversible, and topical pathway for cosmetic research applications. The inhibition of acetylcholine release results in visible muscular relaxation, which helps smooth the appearance of dynamic wrinkles on areas such as the forehead, crow’s feet, and nasolabial folds.

Additionally, Acetyl Octapeptide-1 enhances dermal fibroblast activity and collagen synthesis, contributing to long-term skin repair and firmness. Research indicates that it can increase pro-collagen I and elastin expression, improving dermal thickness and biomechanical resilience.

On a molecular level, Acetyl Octapeptide-1 modulates calcium ion flux and synaptosomal membrane potential, providing a dual neuromodulatory and structural support effect. This makes it an ideal subject for investigating peptide-mediated modulation of neuromuscular communication and ECM remodeling in cosmetic dermatology.

Side Effects

Acetyl Octapeptide-1 has been extensively evaluated in vitro and ex vivo and is regarded as low in cytotoxicity and irritation potential. Commonly observed effects in research settings include minor skin sensitivity at high concentrations (>10%), which is reversible. No systemic toxicity, allergenic responses, or mutagenic effects have been reported in preclinical studies.

Researchers are advised to handle all peptide materials in accordance with standard laboratory biosafety and chemical handling protocols. Since this product is for research use only, it should not be applied to humans or animals in any clinical or therapeutic context.

Keywords

Acetyl Octapeptide-1; SNAP-8; anti-wrinkle peptide; cosmetic peptide supplier; peptide raw material China; high-purity cosmetic peptides; OEM peptide factory; lab-grade cosmetic peptides; peptide wholesale China; ≥99% purity peptides; factory peptide supplier; peptide bulk powder

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.