Description

Product Description

Acetyl pentapeptide-1 is a synthetic bioactive pentapeptide designed to mimic natural skin-repair signaling molecules. It plays a crucial role in promoting the skin’s natural defense and regeneration systems. In cosmetic research, it is recognized as an effective ingredient for restoring the barrier function and reinforcing the skin’s resistance to environmental stress, UV radiation, and inflammation.

At the molecular level, Acetyl pentapeptide-1 functions as a messenger peptide that stimulates the synthesis of key structural proteins in the epidermis, such as keratin, involucrin, and filaggrin, which are essential for maintaining the skin’s protective barrier. It also supports the repair of damaged tissues by accelerating the turnover of corneocytes and enhancing intercellular lipid cohesion.

When combined with other short-chain peptides such as Acetyl hexapeptide-8 or Palmitoyl tripeptide-5, it demonstrates synergistic efficacy in promoting barrier recovery and maintaining skin homeostasis. This makes Acetyl pentapeptide-1 an excellent candidate for inclusion in advanced cosmetic research formulations focused on restoring the integrity of sensitive or compromised skin.

From a biochemical perspective, this peptide works by activating genes involved in cell communication and epidermal differentiation. It increases the production of integrins and laminins, both of which contribute to dermal-epidermal junction reinforcement. Through this mechanism, Acetyl pentapeptide-1 not only improves hydration and barrier strength but also reduces transepidermal water loss (TEWL), an indicator of healthy skin.

Recent research has highlighted its ability to modulate inflammatory mediators such as interleukin-1 (IL-1) and prostaglandin E2 (PGE2), reducing irritation responses while maintaining cellular balance. These properties make it especially useful in research models evaluating skin barrier restoration following environmental stress, UV damage, or exposure to harsh cosmetic actives.

In laboratory formulations, Acetyl pentapeptide-1 has been shown to enhance the structural recovery of the stratum corneum and improve resistance to oxidative damage. The acetyl modification enhances peptide stability and lipid compatibility, ensuring deep penetration and sustained bioactivity in experimental cosmetic formulations.

Its versatile function extends beyond simple hydration and repair — it also aids in the regulation of antimicrobial peptides (AMPs) such as β-defensins, contributing to the maintenance of a healthy skin microbiome. This multifaceted role has positioned Acetyl pentapeptide-1 as a leading research peptide in the field of skin barrier biology and regenerative peptide design.

Product Specifications

Mechanism of Action

Acetyl pentapeptide-1 operates as a biomimetic peptide that triggers epidermal renewal pathways and enhances intercellular communication. Its mechanism centers on promoting differentiation of keratinocytes, improving lipid synthesis, and reinforcing tight junctions that maintain skin barrier integrity.

1. Epidermal Differentiation and Barrier Formation

The peptide upregulates genes such as involucrin, filaggrin, and loricrin, which are crucial in forming the corneocyte envelope. These proteins strengthen the stratum corneum, reducing permeability and enhancing skin smoothness. Laboratory studies demonstrate increased TEER (transepithelial electrical resistance) values, indicating improved barrier cohesion.

2. Stimulation of Structural Protein and Lipid Production

Acetyl pentapeptide-1 boosts ceramide and cholesterol synthesis within keratinocytes. This lipid replenishment reduces dryness and irritation while maintaining hydration. Enhanced structural lipid formation ensures greater resilience against pollutants and chemical irritants.

3. Regulation of Inflammatory Pathways

By downregulating pro-inflammatory cytokines (IL-1α, TNF-α) and COX-2 enzymes, Acetyl pentapeptide-1 minimizes inflammation-related barrier disruption. Its soothing and stabilizing properties make it ideal for research on sensitive or compromised skin.

4. Antioxidant and Protective Role

The peptide indirectly enhances antioxidant enzyme activity, particularly glutathione peroxidase and superoxide dismutase (SOD), protecting cells from oxidative stress. This action supports the skin’s ability to recover from UV-induced or pollution-related oxidative damage.

5. Synergistic Barrier Repair with Other Peptides

When used alongside palmitoyl peptides or acetyl hexapeptides, Acetyl pentapeptide-1 enhances both structural reinforcement and communication between epidermal and dermal cells. The result is an optimized model for studying multi-pathway barrier recovery and hydration retention.

Side Effects

In laboratory-based evaluations, Acetyl pentapeptide-1 exhibits excellent biocompatibility. It shows negligible cytotoxicity, minimal irritation, and no sensitization in reconstructed epidermal models.

Potential variations in test results may occur depending on solvent type, pH balance, and peptide concentration. It is advised to conduct preliminary cytotoxicity assays before integrating the peptide into formulation testing.

The peptide should be protected from high temperatures and prolonged UV exposure to preserve stability. It is intended strictly for controlled research use and not for human or animal administration.

Keywords

Acetyl pentapeptide-1, skin barrier repair peptide, skin protection, soothing peptide, epidermal regeneration, cosmetic peptide, peptide research, peptide supplier China, OEM peptide manufacturer, high-purity cosmetic peptides

Shipping Guarantee

All Acetyl pentapeptide-1 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Acetyl pentapeptide-1 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Acetyl pentapeptide-1 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Acetyl pentapeptide-1 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.