Description

Product Description

Acetyl Tetrapeptide-15 is a synthetic derivative of endomorphin-2, engineered for laboratory research in sensitive skin cosmetic studies. Its sequence, Tyr-Pro-Phe-Phe-NH₂, acts as an opioid receptor ligand, selectively engaging μ-opioid pathways to modulate neuronal excitability. This mechanism is central to reducing skin hyperreactivity, including inflammatory, chronic, and neuropathic stress responses in epidermal and dermal models.

The peptide works by raising the threshold of neuronal excitability, effectively desensitizing skin to over-stimulation and reducing the downstream production of inflammatory mediators. This function has been observed in ex vivo and in vitro studies, where Acetyl Tetrapeptide-15 decreased pro-inflammatory cytokine expression and improved epidermal barrier homeostasis. Its activity is particularly relevant for cosmetic research targeting conditions such as sensitive skin, redness-prone skin, and mild irritation caused by environmental stressors or topical actives.

Structurally, the acetylation of the N-terminus enhances peptide stability and prolongs biological activity, allowing researchers to investigate its effects in various carrier systems, including serums, creams, and emulsions. Laboratory studies indicate that it can synergize with other peptides, antioxidants, or barrier-supporting molecules to provide multi-targeted anti-irritation effects.

Beyond its desensitization properties, Acetyl Tetrapeptide-15 is linked to cellular resilience, supporting keratinocyte and fibroblast function under mild stress conditions. This makes it an important tool for researchers developing formulations aimed at calming reactive skin or preventing inflammation-induced barrier disruption. As a cosmetic peptide research material, it provides a reproducible and high-purity option for mechanistic studies, topical bioavailability assays, and formulation efficacy experiments.

Product Specifications

Mechanism of Action

1. μ-Opioid Receptor Modulation

Acetyl Tetrapeptide-15 functions as a selective agonist at μ-opioid receptors in epidermal neurons. By binding to these receptors, it raises the excitation threshold of nociceptive pathways, reducing the perception of chemical and mechanical stress in skin models. This pathway mimics natural endorphin activity, providing an endorphin-like calming effect on skin cells.

2. Anti-Inflammatory Effects

The peptide reduces the expression of key pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, which are associated with sensitive or reactive skin. By attenuating these signaling molecules, Acetyl Tetrapeptide-15 decreases inflammatory responses, contributing to a more resilient epidermal barrier.

3. Barrier Function Enhancement

Research has demonstrated that Acetyl Tetrapeptide-15 indirectly supports keratinocyte function, promoting cell-cell adhesion and strengthening the stratum corneum. This improves overall barrier integrity, which is essential for preventing transepidermal water loss and maintaining skin homeostasis under irritant exposure.

4. Neurological Desensitization

By modulating the excitability of peripheral neurons via μ-opioid receptor pathways, the peptide increases the threshold for nociceptive firing. This mechanism reduces neurogenic inflammation and contributes to a calmer response to environmental stressors, UV exposure, and cosmetic actives.

5. Synergistic Effects with Cosmetic Peptides

In combination studies, Acetyl Tetrapeptide-15 has been evaluated alongside other bioactive peptides, antioxidants, and barrier-strengthening agents. The synergy provides multi-targeted benefits, enhancing overall skin tolerance and mitigating reactive responses in sensitive skin research.

Side Effects

Acetyl Tetrapeptide-15 has demonstrated a favorable safety profile in in vitro and ex vivo studies. At typical laboratory concentrations, it shows minimal cytotoxicity and does not elicit phototoxic or allergenic responses. However, as with all experimental peptides:

• Handle with standard laboratory precautions.

• Avoid direct ingestion, injection, or application on humans or animals.

• Peptide stability is influenced by pH, solvent composition, and prolonged exposure to high temperature or light.

Keywords

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Shipping Guarantee

All Acetyl Tetrapeptide-15 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Acetyl Tetrapeptide-15 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Acetyl Tetrapeptide-15 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Acetyl Tetrapeptide-15 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.