Description

Product Description

Acetyl tetrapeptide-5 is a small synthetic peptide designed for cosmetic and dermatological research focusing on anti-aging, skin firming, and anti-edema applications. Composed of four amino acids, this peptide exhibits remarkable biological activity by improving the skin’s moisture balance and structural integrity. It acts primarily on microvascular blood flow and extracellular matrix remodeling, both of which are vital to maintaining youthful, smooth, and firm skin.

In research studies, Acetyl tetrapeptide-5 has been shown to inhibit glycosylation and ACE-1 activity, two processes linked to fluid retention and vascular stress in the skin. This dual mechanism helps to visibly reduce edema, puffiness, and under-eye bags. The peptide’s gentle yet effective modulation of vascular permeability allows for better lymphatic drainage and improved skin clarity. As such, it serves as a key model compound in cosmetic peptide studies related to skin elasticity, firmness, and rejuvenation.

Furthermore, Acetyl tetrapeptide-5 contributes to enhancing the biomechanical properties of the dermal matrix. It boosts the expression of collagen and elastin, reinforcing dermal resilience and skin turgor. Its application in cosmetic research extends beyond topical formulations; it is also utilized in biochemical studies examining peptide-mediated vascular regulation and antioxidant protection. Because oxidative stress and glycation both contribute to skin aging, Acetyl tetrapeptide-5 provides a unique experimental pathway for investigating anti-glycation mechanisms and dermal microcirculation improvement.

From an industrial research standpoint, Acetyl tetrapeptide-5 is widely studied in connection with peptide-based formulations for skin-firming serums, eye creams, and hydrating gels. The peptide is often combined with humectants and plant-based extracts to maximize hydration and firmness. Its excellent skin compatibility and high purity (≥99%) make it an ideal candidate for controlled laboratory studies aimed at the development of innovative cosmetic actives.

Product Specifications

Mechanism of Action

Acetyl tetrapeptide-5 exerts its biological activity by targeting multiple pathways that regulate skin hydration, vascular permeability, and collagen synthesis. The peptide’s structural sequence enables specific interaction with receptors associated with the renin–angiotensin system and glycation processes, both of which contribute to dermal fatigue and swelling.

1. Inhibition of ACE-1 and Glycation

By inhibiting angiotensin-converting enzyme (ACE-1), Acetyl tetrapeptide-5 limits the local production of angiotensin II, which otherwise promotes vasoconstriction and fluid retention. The peptide’s anti-glycation effect prevents the formation of advanced glycation end-products (AGEs) that stiffen the dermal matrix, reducing elasticity and contributing to the visible signs of aging. Through this dual inhibition, Acetyl tetrapeptide-5 restores the skin’s suppleness and reduces the dullness associated with vascular stagnation.

2. Enhancement of Microcirculation and Lymphatic Drainage

Research has shown that Acetyl tetrapeptide-5 can improve blood flow and lymphatic clearance, particularly in periorbital tissues. By reinforcing the capillary walls and modulating vascular tone, it helps to alleviate puffiness under the eyes and brighten the overall complexion. The peptide is also known to improve oxygen and nutrient delivery to skin cells, optimizing dermal metabolism and enhancing vitality.

3. Collagen and Elastin Upregulation

Acetyl tetrapeptide-5 supports extracellular matrix renewal by stimulating fibroblasts to synthesize collagen types I and III, as well as elastin. This mechanism results in better skin firmness and a reduction in fine lines and wrinkles. Studies indicate that prolonged exposure to the peptide in vitro leads to a measurable increase in dermal thickness and elasticity.

4. Antioxidant and Anti-inflammatory Effects

The peptide exhibits mild antioxidant properties, reducing reactive oxygen species (ROS) generation and protecting skin cells from oxidative stress. It also downregulates pro-inflammatory cytokines, helping to maintain a balanced skin barrier environment.

Together, these mechanisms make Acetyl tetrapeptide-5 an essential subject of study in anti-aging and skin-firming research. Its molecular versatility and excellent biocompatibility make it a reference standard in peptide-based skincare investigations.

Side Effects

In research contexts, Acetyl tetrapeptide-5 has demonstrated excellent safety and skin tolerance. It does not cause irritation, sensitization, or cytotoxicity at standard concentrations used in in vitro and ex vivo studies. As with all peptides, potential risks include minor instability if improperly stored, leading to degradation or reduced activity. No adverse biological reactions have been observed under standard laboratory testing conditions. Researchers are advised to handle this peptide following standard biosafety and chemical handling protocols.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.