Description

Product Description

Acetyl tripeptide-30 citrulline is a synthetic tripeptide derivative engineered for advanced cosmetic and dermatological research focused on skin rejuvenation. This peptide acts as a cellular messenger that regulates skin renewal pathways, helping to restore firmness and elasticity lost through aging or environmental stress. Its sequence includes citrulline, a naturally occurring amino acid known to enhance nitric oxide production and promote cellular oxygenation, which supports healthy skin metabolism.

Researchers have identified that Acetyl tripeptide-30 citrulline plays a crucial role in stimulating dermal matrix protein synthesis, including collagen types I and III, fibronectin, and elastin. By supporting fibroblast activity, it improves the structural integrity of the skin and reduces fine lines and wrinkles. Moreover, its acetylated modification enhances stability and bioavailability, allowing it to effectively penetrate the stratum corneum during topical formulation studies.

In vitro assays demonstrate that Acetyl tripeptide-30 citrulline promotes upregulation of genes associated with extracellular matrix regeneration and downregulation of inflammatory cytokines that contribute to skin aging. This dual mechanism of action makes it particularly valuable for anti-aging and anti-wrinkle peptide research.

From a biochemical standpoint, Acetyl tripeptide-30 citrulline exhibits amphiphilic behavior that facilitates interaction with lipid bilayers, supporting deeper diffusion into the epidermis. This property has led researchers to explore its synergistic potential with other peptides, such as palmitoyl tripeptides and acetyl hexapeptides, to achieve comprehensive anti-aging effects.

Studies in cosmetic science have reported its potential in increasing dermal density, improving skin tone uniformity, and minimizing wrinkle depth in controlled laboratory conditions. Due to its multifunctional role as both a collagen stimulator and a skin barrier enhancer, Acetyl tripeptide-30 citrulline serves as an important molecule in peptide formulation research targeting visible signs of skin aging.

Product Specifications

Mechanism of Action

Acetyl tripeptide-30 citrulline acts primarily as a signaling peptide, influencing the molecular communication between keratinocytes and fibroblasts. This interaction is central to maintaining dermal homeostasis and extracellular matrix integrity. The inclusion of citrulline in the peptide chain is particularly relevant for skin biology because citrulline acts as a nitric oxide precursor, enhancing vasodilation and nutrient delivery to skin cells.

1. Collagen Stimulation Pathway

This peptide enhances the expression of TGF-β (Transforming Growth Factor Beta), which triggers the SMAD signaling cascade responsible for collagen synthesis. Upregulation of this pathway contributes to improved skin elasticity and firmness. Laboratory results have shown significant increases in collagen I and III mRNA expression within fibroblast cultures treated with Acetyl tripeptide-30 citrulline.

2. Inhibition of Matrix Metalloproteinases (MMPs)

MMPs degrade structural proteins in the dermis, accelerating the aging process. Acetyl tripeptide-30 citrulline suppresses the transcription of MMP-1 and MMP-9, thereby preserving collagen integrity. This anti-collagenase effect supports long-term dermal repair.

3. Anti-Inflammatory Modulation

The peptide also decreases the expression of pro-inflammatory markers such as IL-6, TNF-α, and COX-2, which are known contributors to premature skin aging. Through this mechanism, it helps maintain balanced inflammatory signaling and improves skin comfort, especially in sensitive skin models.

4. Skin Barrier Enhancement

By supporting the production of key epidermal lipids and proteins, this peptide reinforces the skin barrier. Improved hydration and barrier repair lead to better resilience against oxidative stress and environmental damage.

5. Synergistic Peptide Activity

When combined with other active peptides such as palmitoyl tripeptide-5 or acetyl hexapeptide-37, Acetyl tripeptide-30 citrulline exhibits complementary effects, making it a suitable ingredient for advanced anti-aging research formulations targeting multiple aging pathways simultaneously.

Side Effects

In controlled laboratory research, Acetyl tripeptide-30 citrulline has demonstrated a favorable safety profile with minimal cytotoxicity at research concentrations. No significant irritation, sensitization, or phototoxic reactions were reported in reconstructed human epidermal models.

As with all peptide research materials, variations in concentration, solvent composition, and pH conditions may influence biocompatibility outcomes. It is advisable to perform concentration-dependent cytotoxicity tests prior to formulation development. Peptide stability should be maintained by preventing prolonged exposure to high temperatures or direct UV light.

Due to its biochemical nature, the peptide is considered safe for experimental use under controlled laboratory conditions, but not intended for ingestion, injection, or direct therapeutic use.

Keywords

Acetyl tripeptide-30 citrulline, anti-wrinkle peptide, skin regeneration, collagen synthesis, cosmetic peptide, peptide research, peptide supplier China, OEM cosmetic peptides, high-purity peptide powder

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.