描述
Adenosylmethionine (SAMe) is a key endogenous methyl donor involved in transmethylation and trans-sulfuration reactions. Its disulfate tosylate formulation is used in injectable form to protect liver cell membranes, enhance glutathione and coenzyme A synthesis, and facilitate bile flow. Widely utilized in preclinical research on cholestatic hepatitis, liver fibrosis, and metabolic liver injury.
Adenosylmethionine Disulfate Tosylate Injection Product Specifications
Parameter | Details |
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Product Name | Adenosylmethionine Disulfate Tosylate Injection (Baixino) |
Generic Name | S-Adenosyl-L-methionine Disulfate Tosylate |
CAS Number | 97540?22?2 |
Molecular Formula | C??H??N?O?S·C?H?O?S·2H?SO? |
Molecular Weight | ?766.8?g/mol |
Dosage Form | Lyophilized powder for injection with solvent |
Dosage per Vial | 0.5?g SAMe (as disulfate tosylate) |
Pack Size | 5 vials + 5 vials of provided solvent |
Approval Number | H20193344 |
Drug Standard Code | 86901523002291 |
Manufacturer | CSPC Tianqing Pharmaceutical Group Co., Ltd. |
Barcode | Not yet assigned |
Storage Conditions | Store at 2–8?°C, protected from light |
Intended Use | Laboratory research and preclinical liver function studies |
Adenosylmethionine Disulfate Tosylate Injection Mechanism of Action
SAMe acts as a universal methyl group donor in vital biochemical pathways, supporting liver cell membrane integrity, glutathione synthesis, and bile detox pathways. It enhances cellular resilience to oxidative and cholestatic injury .
Research Application Areas
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Models of cholestatic and drug?induced liver injury
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Prevention of intrahepatic bile stasis and fibrosis
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Studies of transmethylation and trans?sulfuration pathways
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Enhancement of antioxidant defenses in hepatocytes
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Comparative research vs. ursodeoxycholic acid in hepatic protection
Research shows SAMe improves liver tests and reduces fibrosis markers without significant adverse effects in these models ChinaGPDrugBank.
Safety & Handling
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Adverse Effects: Rare mild gastrointestinal discomfort or sleep disturbances .
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Reconstitution: Reconstitute each vial with supplied solvent before clinical studies.
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Handling: Use standard lab PPE—gloves, eyewear, coat; avoid aerosol contact.
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Storage: Maintain 2–8?°C; do not freeze; protect from light.
Core Keywords
Adenosylmethionine disulfate injection, SAMe injection, H20193344, hepatoprotective injection, liver fibrosis research, methyl donor injection, wholesale SAMe vials, lab-grade SAMe
Research Use Disclaimer
This product is strictly for laboratory and preclinical research use. It is not approved for therapeutic, diagnostic, or veterinary applications. Misuse may bear legal and health consequences. Use only under institutional protocols and regulatory oversight.
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